{"id":"W4224272857","doi":"10.1017/cts.2022.138","title":"255 A Bacterial Serine Protease Inhibitor, Ecotin Inhibits Neutrophil Elastase in Cystic Fibrosis Airway Samples","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical and Translational Science","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Sputum; Neutrophil elastase; Biology; Proteases; Elastase; Microbiology; Immunology; Molecular biology; Inflammation; Biochemistry; Medicine; Pathology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002816982,0.0003107716,0.0002790648,0.0002241427,0.000122817,0.0002541075,0.0001633081,0.0002597997,0.001525123],"category_scores_gemma":[0.0003957397,0.0001006009,0.0002182496,0.0001591524,0.0001080468,0.0001225005,0.0001364748,0.0003184589,0.000394142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001515286,"about_ca_system_score_gemma":0.0001660638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006279426,"about_ca_topic_score_gemma":0.001311449,"domain_scores_codex":[0.9997609,0.00004570272,0.00003004604,0.0000402805,0.00008480102,0.00003825162],"domain_scores_gemma":[0.9998626,0.000026021,0.00003510627,0.00001066253,0.00003947729,0.00002611179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003480848,0.000132059,0.002768937,0.00008880375,0.00001468692,0.00009942135,0.00001263418,0.0000575546,0.9909744,0.0000126821,0.0001066574,0.00538412],"study_design_scores_gemma":[0.00005123791,0.002325043,0.06422675,0.00004031094,0.00004646022,0.001369247,0.00005612414,0.001754155,0.9256406,0.00002410389,0.004458244,0.000007706343],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909089,0.004880423,0.001915549,0.00008182786,0.00005100109,0.00008821532,0.0003649616,0.00003576462,0.001673221],"genre_scores_gemma":[0.9883753,0.00141437,0.005529109,0.000136553,0.00002280082,0.00006840283,0.001533877,0.0000101374,0.002909364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001525123,"threshold_uncertainty_score":0.005102098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02233706569727924,"score_gpt":0.3039600819660407,"score_spread":0.2816230162687615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}