{"id":"W4224272857","doi":"10.1017/cts.2022.138","title":"255 A Bacterial Serine Protease Inhibitor, Ecotin Inhibits Neutrophil Elastase in Cystic Fibrosis Airway Samples","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical and Translational Science","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Sputum; Neutrophil elastase; Biology; Proteases; Elastase; Microbiology; Immunology; Molecular biology; Inflammation; Biochemistry; Medicine; Pathology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001307023,0.00007000558,0.0001391744,0.00008193419,0.000143704,0.00002833281,0.0001187053,0.00003456945,0.0001048882],"category_scores_gemma":[0.0002457171,0.00006096292,0.00006547743,0.000224172,0.0001982533,0.00003253929,0.00005444646,0.0001851956,5.786019e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005532578,"about_ca_system_score_gemma":0.0002892473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002374322,"about_ca_topic_score_gemma":0.000006458784,"domain_scores_codex":[0.9986652,0.0001228,0.0005873782,0.0002098666,0.0003004108,0.0001143169],"domain_scores_gemma":[0.999464,0.00003188151,0.0002095277,0.00006677517,0.0001139027,0.0001139419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001866737,0.0004821309,0.08763067,0.00002127369,0.00001126158,0.000007999974,0.00009577286,0.001251323,0.8920211,0.0002210447,0.0001779207,0.01621284],"study_design_scores_gemma":[0.006560277,0.003466835,0.7390323,0.00006785922,0.00003757642,0.0003306729,0.00009458872,0.0005031355,0.1459339,0.001504274,0.1020252,0.0004433844],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971321,0.0001365039,0.0002428474,0.001930705,0.0003948545,0.00009475688,0.00004189753,0.000001856664,0.00002449483],"genre_scores_gemma":[0.998094,0.00007029769,0.001057499,0.0001469847,0.0005601009,0.00000681212,0.00002566158,0.000004428456,0.00003427696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7460871,"threshold_uncertainty_score":0.2485996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02233706569727924,"score_gpt":0.3039600819660407,"score_spread":0.2816230162687615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}