{"id":"W4224278198","doi":"10.1101/2022.04.06.487252","title":"Prostaglandins and calprotectin are genetically and functionally linked to the Inflammatory Bowel Diseases","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University Health Centre; Montreal Heart Institute","funders":"Broad Institute; Institut de Cardiologie de Montréal; Université de Montréal; Department of Epidemiology, Biostatistics and Occupational Health, McGill University; McGill University Health Centre; McGill University","keywords":"Biology; Genome-wide association study; Transcriptome; Inflammatory bowel disease; S100A9; Gene; Genetics; Gene expression; Computational biology; Single-nucleotide polymorphism; Medicine; Disease; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005897006,0.0004136515,0.0003829763,0.0002241962,0.0006695261,0.0001456169,0.0003371354,0.0004300845,0.0002107472],"category_scores_gemma":[0.0004316196,0.0003498031,0.00008627897,0.0001745215,0.0002234372,0.0000778805,0.001061987,0.0009612347,0.00008191697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001220739,"about_ca_system_score_gemma":0.0003888392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002856145,"about_ca_topic_score_gemma":0.000006331689,"domain_scores_codex":[0.9978039,0.0004705383,0.0004493924,0.00073532,0.0001199222,0.0004208846],"domain_scores_gemma":[0.9984737,0.0001576009,0.0002982709,0.0007697615,0.0002066123,0.00009402874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007864847,0.0001096718,0.04127204,0.0003669514,0.0004585722,0.00003775114,0.00009220596,0.00009138737,0.9542457,0.0006536243,0.001856307,0.00002934422],"study_design_scores_gemma":[0.0006488518,0.0001369585,0.8903061,0.0001340892,0.0001408402,2.131649e-7,0.00002437073,0.00002376074,0.01978247,0.000003816524,0.08830801,0.0004905778],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866986,0.008310127,0.0002222102,0.001785953,0.00101291,0.001477894,0.0002898987,0.000197689,0.000004711],"genre_scores_gemma":[0.9976993,0.0004854335,0.000134018,0.0004707154,0.0001819798,0.0008787949,0.000003120511,0.00006620212,0.00008045776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9344632,"threshold_uncertainty_score":0.9998954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008187806371365224,"score_gpt":0.1990029029842177,"score_spread":0.1908150966128524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}