{"id":"W4224278198","doi":"10.1101/2022.04.06.487252","title":"Prostaglandins and calprotectin are genetically and functionally linked to the Inflammatory Bowel Diseases","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University Health Centre; Montreal Heart Institute","funders":"Broad Institute; Institut de Cardiologie de Montréal; Université de Montréal; Department of Epidemiology, Biostatistics and Occupational Health, McGill University; McGill University Health Centre; McGill University","keywords":"Biology; Genome-wide association study; Transcriptome; Inflammatory bowel disease; S100A9; Gene; Genetics; Gene expression; Computational biology; Single-nucleotide polymorphism; Medicine; Disease; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001806405,0.0002784411,0.0002436555,0.0006359663,0.0001256773,0.0002622183,0.0001314211,0.0002440392,0.001812145],"category_scores_gemma":[0.0002184171,0.00009812251,0.0002602075,0.000474122,0.0002012896,0.00008180091,0.0001925412,0.000416913,0.00016689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001903006,"about_ca_system_score_gemma":0.0001379917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003762611,"about_ca_topic_score_gemma":0.0004175142,"domain_scores_codex":[0.9998411,0.0000385419,0.00001351018,0.00005234294,0.00003242432,0.00002206962],"domain_scores_gemma":[0.999756,0.00004068933,0.0001379792,0.00001567801,0.00001352754,0.00003599742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002526406,0.0001305662,0.1137984,0.0003636675,0.0002367297,0.001085929,0.00005183403,0.0002971789,0.8673593,0.0005738005,0.0002456766,0.01333048],"study_design_scores_gemma":[0.00007118412,0.0006005407,0.8615614,0.00005096696,0.0003308057,0.003352433,0.0001126703,0.001058642,0.1286921,0.0007075199,0.003447621,0.0000141523],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920133,0.003828594,0.001754502,0.0001938703,0.00002383703,0.00001757673,0.001308759,0.00004035434,0.0008193292],"genre_scores_gemma":[0.996276,0.001121278,0.001407478,0.00006032395,0.00002068895,0.0000169618,0.000560681,0.000005401783,0.0005312014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001812145,"threshold_uncertainty_score":0.006062269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008187806371365224,"score_gpt":0.1990029029842177,"score_spread":0.1908150966128524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}