{"id":"W4224280907","doi":"10.21203/rs.3.rs-1555653/v1","title":"Transgenic TDP-43 and endogenous TDP-1 Caenorhabditis elegans ALS models show motor deficits and age-dependent neurodegeneration","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Neurodegeneration; TARDBP; Amyotrophic lateral sclerosis; Caenorhabditis elegans; Transgene; Biology; Neuroscience; Mutation; Phenotype; Genetically modified mouse; Mutant; Genetics; Gene; SOD1; Disease; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001733544,0.0007217976,0.0003243205,0.0006003081,0.0003472104,0.0002977642,0.0003699621,0.0006916002,0.002784356],"category_scores_gemma":[0.0001440817,0.0002153041,0.0003588327,0.0002411323,0.0003733344,0.0003072851,0.0004374964,0.001026334,0.001024823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006176179,"about_ca_system_score_gemma":0.0003389953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003035755,"about_ca_topic_score_gemma":0.004569157,"domain_scores_codex":[0.9997033,0.00001916706,0.00002699537,0.0000839889,0.000121269,0.00004513498],"domain_scores_gemma":[0.9998771,0.00001914909,0.00003395197,0.00001509295,0.00001914675,0.00003552633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008228649,0.0000449554,0.0001455254,0.00007026646,0.000008638978,0.0001423897,0.00001798273,0.0001309237,0.9968762,0.0004572398,0.0003831627,0.001640358],"study_design_scores_gemma":[0.00004653833,0.0001547945,0.003318047,0.0000349492,0.00002396879,0.0005789815,0.00003911282,0.002630139,0.9795188,0.0002861646,0.01335079,0.00001770855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9318914,0.003488286,0.03354494,0.00124986,0.0007724578,0.0002552728,0.008677703,0.001310697,0.01880928],"genre_scores_gemma":[0.9024019,0.001997882,0.03577829,0.0003716106,0.00003772958,0.0003108573,0.005472093,0.0006168503,0.05301284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003035755,"threshold_uncertainty_score":0.009314537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1690265899436563,"score_gpt":0.3707203381032778,"score_spread":0.2016937481596215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}