{"id":"W4224282832","doi":"10.1002/mds.29027","title":"Neurofilament Light Protein as a Potential Blood Biomarker for Huntington's Disease in Children","year":2022,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; Medical Research Council; Eunice Kennedy Shriver National Institute of Child Health and Human Development; CHDI Foundation; Medical Research Council Canada; Hereditary Disease Foundation; Huntington's Disease Society of America","keywords":"Huntington's disease; Biomarker; Medicine; Putamen; Internal medicine; Population; Disease; Oncology; Pediatrics; Endocrinology; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001336654,0.0002707271,0.0001662256,0.0002165425,0.000430376,0.00007904802,0.0004603262,0.00001676234,0.0004371496],"category_scores_gemma":[0.0002199586,0.000296934,0.0001727164,0.000391672,0.00006020796,0.00008681316,0.000417753,0.0001269963,0.0000131212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005631878,"about_ca_system_score_gemma":0.0001089328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008475317,"about_ca_topic_score_gemma":0.0000120484,"domain_scores_codex":[0.9973049,0.0002890698,0.0003190007,0.0009106215,0.0006285543,0.0005478124],"domain_scores_gemma":[0.9992533,0.0000306524,0.0001273119,0.0004014333,0.00001592282,0.0001713348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003861901,0.00264434,0.05537115,0.00002971697,0.00002418257,0.00001566262,0.0001021261,0.004008018,0.9338334,0.001417961,0.001118487,0.001048767],"study_design_scores_gemma":[0.005569033,0.0008259166,0.1692855,0.00001484753,0.0001079079,4.378088e-7,0.0001695763,0.001716809,0.8011439,0.01864346,0.001710009,0.0008126333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909651,0.00006862391,0.00009172848,0.004523667,0.0002011443,0.003661647,0.0001943403,0.00007398748,0.0002197712],"genre_scores_gemma":[0.9888188,0.0000125229,0.00004448019,0.00693501,0.00002752189,0.00335972,0.00004069656,0.00005709971,0.0007041746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1326895,"threshold_uncertainty_score":0.9999483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00867374604475993,"score_gpt":0.2307768824885623,"score_spread":0.2221031364438024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}