{"id":"W4224286201","doi":"10.3390/cells11091391","title":"Cannabinoids Alleviate the LPS-Induced Cytokine Storm via Attenuating NLRP3 Inflammasome Signaling and TYK2-Mediated STAT3 Signaling Pathways In Vitro","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"Mitacs","keywords":"Inflammasome; Pyrin domain; Proinflammatory cytokine; Signal transduction; Cytokine; Pyroptosis; Inflammation; Cannabidiol; Pharmacology; Immunology; Chemistry; Biology; Cell biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000140666,0.0004999724,0.0007180435,0.0004491264,0.0002736259,0.000319367,0.0002396103,0.0003407247,0.002344312],"category_scores_gemma":[0.0001334675,0.0001757521,0.0005475325,0.0002835134,0.000273657,0.0003232259,0.0003201475,0.001221904,0.0005525361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00036487,"about_ca_system_score_gemma":0.0006186957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001963367,"about_ca_topic_score_gemma":0.004811291,"domain_scores_codex":[0.9998174,0.00002012566,0.00002715643,0.00002391702,0.00005261075,0.00005885071],"domain_scores_gemma":[0.9999292,0.00000803269,0.00001644198,0.000009811643,0.00001372121,0.00002277217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002003932,0.0004293491,0.0002905678,0.000367754,0.00003052625,0.0001471622,0.00004659472,0.0001469524,0.9906489,0.0001255664,0.0003887278,0.005374006],"study_design_scores_gemma":[0.0003777344,0.00233949,0.005413857,0.00004368113,0.0001078463,0.000334252,0.0001099124,0.001663215,0.9817634,0.0002197853,0.007605117,0.0000216948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9668932,0.01934564,0.004600648,0.0008348026,0.0004316757,0.0001513438,0.00256099,0.000342108,0.004839706],"genre_scores_gemma":[0.9804025,0.007836639,0.003634491,0.000400034,0.00006800575,0.0001680342,0.001738266,0.00003713147,0.005714885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002344312,"threshold_uncertainty_score":0.007842481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009600461808859309,"score_gpt":0.2043239856847733,"score_spread":0.1947235238759139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}