{"id":"W4224289790","doi":"10.1016/j.bmcl.2022.128744","title":"Arabinonucleic acids containing C5-propynyl modifications form stable hybrid duplexes with RNA that are efficiently degraded by E. coli RNase H","year":2022,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Concordia University","funders":"Natural Sciences and Engineering Research Council of Canada; Concordia University","keywords":"Oligonucleotide; Propynyl; Chemistry; Nucleic acid; Nuclease; RNase H; RNA; DNA; RNase P; Phosphoramidite; Combinatorial chemistry; Oligomer; Stereochemistry; Oligonucleotide synthesis; Chemical synthesis; Biochemistry; In vitro; Gene; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003871983,0.0004416344,0.0002837332,0.0001946347,0.0002118928,0.0004683763,0.0002560377,0.0005651992,0.001829921],"category_scores_gemma":[0.0004792865,0.0003435248,0.0001983636,0.0001238927,0.0003177683,0.0002990271,0.0002303277,0.0005682695,0.000768413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002612899,"about_ca_system_score_gemma":0.0001626686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002706154,"about_ca_topic_score_gemma":0.0005959092,"domain_scores_codex":[0.9997186,0.00006541088,0.00001714203,0.00007672055,0.00006799553,0.00005405094],"domain_scores_gemma":[0.9995775,0.0001217008,0.0001158891,0.00004978893,0.0000343452,0.0001008196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007310132,0.00001239563,0.00006025804,0.00001037372,0.000007047939,0.00002109016,0.00001806209,0.00006690725,0.9990025,0.0001155819,0.00003020755,0.0005825373],"study_design_scores_gemma":[0.00001379846,0.0001995532,0.000561631,0.000002110137,0.00000968455,0.00007179045,0.00001285794,0.0004552034,0.9975278,0.00003972241,0.001097947,0.000008022842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911151,0.0004979964,0.005764138,0.0000478094,0.00005170267,0.00003884298,0.0001036692,0.0002239089,0.002156843],"genre_scores_gemma":[0.9940899,0.000119295,0.002931262,0.00004932467,0.00001178868,0.00003019625,0.0002109745,0.00006361507,0.002493519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001829921,"threshold_uncertainty_score":0.006121695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00989550883106059,"score_gpt":0.200440064515099,"score_spread":0.1905445556840385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}