{"id":"W4224298869","doi":"10.1107/s2059798322003011","title":"Monoclonal antibody 7H2.2 binds the C-terminus of the cancer-oocyte antigen SAS1B through the hydrophilic face of a conserved amphipathic helix corresponding to one of only two regions predicted to be ordered","year":2022,"lang":"en","type":"article","venue":"Acta Crystallographica Section D Structural Biology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"ImmunoPrecise (Canada); University of Victoria","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Paratope; Epitope; Monoclonal antibody; Immunoglobulin Fab Fragments; Antigen; Peptide; Antigen-Antibody Complex; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002003649,0.0006253464,0.0003982133,0.0003214605,0.0001863899,0.0002553351,0.0004618983,0.0005331933,0.003173211],"category_scores_gemma":[0.000127057,0.0002988238,0.000443271,0.0002065441,0.0002118646,0.0001894365,0.0003836637,0.0008030104,0.001585537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005809538,"about_ca_system_score_gemma":0.0002407895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006157118,"about_ca_topic_score_gemma":0.00111076,"domain_scores_codex":[0.999718,0.00002973057,0.000009970818,0.00006716487,0.0000994338,0.00007569186],"domain_scores_gemma":[0.9999034,0.00001458576,0.00001939192,0.00000898551,0.00001527738,0.00003824456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006322822,0.00002682278,0.0003116812,0.00002078081,0.0000128806,0.000039697,0.000005809392,0.0000490891,0.9979789,0.00006542869,0.0001383301,0.001287578],"study_design_scores_gemma":[0.0001534714,0.000770728,0.01233029,0.00001525837,0.00005410635,0.001521154,0.0000305496,0.002236761,0.9669558,0.0001033261,0.01581249,0.00001617038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864762,0.002029915,0.004751313,0.0002451954,0.00005329866,0.00008540976,0.000388035,0.000176661,0.00579406],"genre_scores_gemma":[0.9857787,0.0009115157,0.005970972,0.0002617333,0.00005072766,0.00005581048,0.002325938,0.00004263951,0.004601791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003173211,"threshold_uncertainty_score":0.01061541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04151102237177752,"score_gpt":0.3431756156796129,"score_spread":0.3016645933078353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}