{"id":"W4224309099","doi":"10.1007/s00441-022-03620-1","title":"Prion-like strain effects in tauopathies","year":2022,"lang":"en","type":"review","venue":"Cell and Tissue Research","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates; Ministry of Advanced Education, Government of Alberta","keywords":"Tau protein; Prion protein; Biology; Neuroscience; Tau pathology; Tauopathy; Mechanism (biology); Neurodegeneration; Computational biology; Disease; Alzheimer's disease; Medicine; Pathology; Philosophy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007400058,0.001328426,0.002023708,0.00219317,0.00028582,0.001282373,0.001047413,0.001639523,0.002917073],"category_scores_gemma":[0.0007347577,0.0003421827,0.0004651605,0.002293018,0.0007315713,0.001229469,0.0008647561,0.00226253,0.001933244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006371059,"about_ca_system_score_gemma":0.0008994328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001042947,"about_ca_topic_score_gemma":0.001941332,"domain_scores_codex":[0.999853,0.00002499303,0.00002109805,0.00002909332,0.00005640652,0.00001546192],"domain_scores_gemma":[0.9997106,0.0001581428,0.00003400312,0.00001085751,0.00005648434,0.00002988901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001567807,0.00008710399,0.0001162377,0.01418321,0.00009451198,0.0003916854,0.00004393661,0.0004565376,0.002738143,0.004455968,0.03690913,0.9403667],"study_design_scores_gemma":[0.00005939154,0.0001190906,0.0009266314,0.004467769,0.0002300334,0.00219166,0.00004494101,0.0001554726,0.00100569,0.005481817,0.9852824,0.00003513508],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004820616,0.9992018,0.00009069801,0.0001179413,0.0001403666,0.000001899775,0.00001202942,0.000004737118,0.0003823262],"genre_scores_gemma":[0.000334826,0.9989052,0.000114851,0.0001094042,0.0001939979,0.000003965626,0.00002102326,0.000001134052,0.0003156364],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002917073,"threshold_uncertainty_score":0.009758592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06838945142820387,"score_gpt":0.4024635209979928,"score_spread":0.334074069569789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}