{"id":"W4224309273","doi":"10.1002/mds.29025","title":"Parkin Deficiency Impairs Mitochondrial <scp>DNA</scp> Dynamics and Propagates Inflammation","year":2022,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Wellcome Trust Centre for Mitochondrial Research; Japan Science and Technology Agency; Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Medical Research Council; Medical Research Council Canada; Bundesministerium für Bildung und Forschung; Universität zu Lübeck; Fonds National de la Recherche Luxembourg; Japan Agency for Medical Research and Development; Deutsche Forschungsgemeinschaft; University of Oxford; Wellcome Trust; Alzheimer's Society; Joachim Herz Stiftung; Deutsches Zentrum für Luft- und Raumfahrt; Eli Lilly and Company; Alzheimer's Research Trust; Michael J. Fox Foundation for Parkinson's Research; Max-Planck-Förderstiftung; Université du Luxembourg; Newcastle University; Hermann und Lilly Schilling-Stiftung für Medizinische Forschung; International Parkinson and Movement Disorder Society; Biogen","keywords":"Parkin; Inflammation; Mitochondrial DNA; Dynamics (music); Neuroscience; Biology; Genetics; Cell biology; Medicine; Immunology; Physics; Parkinson's disease; Gene; Internal medicine; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001113606,0.0002010383,0.0001975826,0.0001403029,0.0003370252,0.00003496858,0.00008125131,0.00003663992,0.0001070156],"category_scores_gemma":[0.00005119817,0.0001882936,0.00008701495,0.000209024,0.00005539359,0.00008577092,0.0001316271,0.000118829,0.00001096961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002759216,"about_ca_system_score_gemma":0.00008024675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008818806,"about_ca_topic_score_gemma":0.00009104539,"domain_scores_codex":[0.9985596,0.00005315258,0.0002327342,0.0003710905,0.0004531814,0.000330231],"domain_scores_gemma":[0.999468,0.00003523385,0.0001080301,0.00021897,0.00002521805,0.0001444902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008337749,0.007328755,0.6972314,0.000865608,0.001377786,0.0003588286,0.005721795,0.001452419,0.03665687,0.03595068,0.01811954,0.1941026],"study_design_scores_gemma":[0.04556708,0.01074597,0.5093529,0.0002102614,0.002500035,0.00002604366,0.03454841,0.09564359,0.01638968,0.1901595,0.09353486,0.001321677],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937764,0.0005893513,0.0008237798,0.001050053,0.0002941195,0.001106831,0.00007604903,0.0000973503,0.002186065],"genre_scores_gemma":[0.9969835,0.0001266067,0.0004398251,0.0006048515,0.00004727185,0.0004689862,0.0003060434,0.00003216815,0.0009907634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1927809,"threshold_uncertainty_score":0.7678389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006104840017421773,"score_gpt":0.2190808705925219,"score_spread":0.2129760305751001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}