{"id":"W4224309273","doi":"10.1002/mds.29025","title":"Parkin Deficiency Impairs Mitochondrial <scp>DNA</scp> Dynamics and Propagates Inflammation","year":2022,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Wellcome Trust Centre for Mitochondrial Research; Japan Science and Technology Agency; Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Medical Research Council; Medical Research Council Canada; Bundesministerium für Bildung und Forschung; Universität zu Lübeck; Fonds National de la Recherche Luxembourg; Japan Agency for Medical Research and Development; Deutsche Forschungsgemeinschaft; University of Oxford; Wellcome Trust; Alzheimer's Society; Joachim Herz Stiftung; Deutsches Zentrum für Luft- und Raumfahrt; Eli Lilly and Company; Alzheimer's Research Trust; Michael J. Fox Foundation for Parkinson's Research; Max-Planck-Förderstiftung; Université du Luxembourg; Newcastle University; Hermann und Lilly Schilling-Stiftung für Medizinische Forschung; International Parkinson and Movement Disorder Society; Biogen","keywords":"Parkin; Inflammation; Mitochondrial DNA; Dynamics (music); Neuroscience; Biology; Genetics; Cell biology; Medicine; Immunology; Physics; Parkinson's disease; Gene; Internal medicine; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001710149,0.0004289295,0.0002994244,0.0002887468,0.0001675156,0.0003788536,0.000152868,0.00028613,0.001705397],"category_scores_gemma":[0.000124562,0.0001289948,0.0001988588,0.0001708089,0.0004394511,0.0002562638,0.0002685888,0.0004382212,0.0003779563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00027463,"about_ca_system_score_gemma":0.0001717554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003105317,"about_ca_topic_score_gemma":0.0004468051,"domain_scores_codex":[0.999832,0.00001972804,0.00002545126,0.00005267131,0.0000385675,0.00003146978],"domain_scores_gemma":[0.9997985,0.00001817399,0.00009380544,0.00001571832,0.0000143282,0.00005950469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002970979,0.00002377212,0.0005373491,0.00007243126,0.000009469362,0.0001182998,0.00001717945,0.00004130934,0.9977506,0.0000656079,0.00003725129,0.001029653],"study_design_scores_gemma":[0.00003840443,0.0003974904,0.01623261,0.00002541221,0.00004324577,0.001520519,0.00007825945,0.0006631885,0.9785336,0.0001407883,0.00232082,0.000005715587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949833,0.001449162,0.002153918,0.00008897342,0.00002141002,0.00001592556,0.0004660953,0.0001319092,0.00068921],"genre_scores_gemma":[0.9971559,0.000564995,0.0009545205,0.00003290307,0.000006928481,0.00001718404,0.0003337482,0.00002453181,0.0009092494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001705397,"threshold_uncertainty_score":0.005705178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006104840017421773,"score_gpt":0.2190808705925219,"score_spread":0.2129760305751001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}