{"id":"W4224311311","doi":"10.2217/fon-2022-0045","title":"A phase III trial of alpelisib + trastuzumab ± fulvestrant versus trastuzumab + chemotherapy in HER2+ <i>PIK3CA</i> -mutated breast cancer","year":2022,"lang":"en","type":"article","venue":"Future Oncology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Trastuzumab; Medicine; Fulvestrant; Oncology; Internal medicine; Breast cancer; Chemotherapy; Cancer; Estrogen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001114618,0.0003542718,0.001236585,0.0004070307,0.000134565,0.00001099496,0.0004345187,0.0003133678,0.006510433],"category_scores_gemma":[0.00004419947,0.0003340945,0.0002591615,0.001219865,0.0002618096,0.00007151088,0.000104724,0.001476748,0.000009070069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003016694,"about_ca_system_score_gemma":0.004180958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001720948,"about_ca_topic_score_gemma":0.001310666,"domain_scores_codex":[0.9959822,0.0006186001,0.0009065102,0.0006888474,0.0009631859,0.000840676],"domain_scores_gemma":[0.9984881,0.0002338781,0.0002784229,0.0005369681,0.0001663309,0.0002963101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6796848,0.01260008,0.0001594419,0.0001635416,0.0004214453,0.001027281,0.004539615,0.0001150018,0.01332763,0.0001152967,0.02360034,0.2642455],"study_design_scores_gemma":[0.7063742,0.03040134,0.0009478512,0.00007256244,0.0001685039,0.0005405919,0.004477333,0.0004435542,0.001575093,0.00002515554,0.2545993,0.0003745366],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9676818,0.001142493,0.00001953552,0.01931926,0.003648501,0.002660631,0.0005486474,0.00008768219,0.004891395],"genre_scores_gemma":[0.9940339,0.0008403607,0.0001803063,0.001114723,0.002113022,0.00106612,0.0001441533,0.00009417443,0.0004132557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.263871,"threshold_uncertainty_score":0.9999111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03373686270539864,"score_gpt":0.405549785522902,"score_spread":0.3718129228175033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}