{"id":"W4224312299","doi":"10.1007/s40123-022-00501-2","title":"Results from a Prospective, Open-Label, Phase 4 Pilot Study of Repository Corticotropin Injection for Moderate and Severe Dry Eye Disease","year":2022,"lang":"en","type":"article","venue":"Ophthalmology and Therapy","topic":"Ocular Surface and Contact Lens","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Mallinckrodt Pharmaceuticals","keywords":"Open label; Medicine; Prospective cohort study; Disease; Ophthalmology; Surgery; Anesthesia; Internal medicine; Clinical trial","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009372702,0.0001171342,0.0002928309,0.0000423845,0.0002961037,0.00001615695,0.00006330381,0.00002715139,0.00002713568],"category_scores_gemma":[0.00001938978,0.0001046993,0.00001608855,0.00006615616,0.00004958457,0.00007437219,0.00007788446,0.0001366228,2.025495e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002139016,"about_ca_system_score_gemma":0.00006931969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000473498,"about_ca_topic_score_gemma":0.000004343909,"domain_scores_codex":[0.9990373,0.0001574796,0.0002251769,0.000366208,0.00009371743,0.0001201531],"domain_scores_gemma":[0.9994394,0.00007055778,0.0001195407,0.0002369709,0.00005708998,0.00007647992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2199367,0.01485051,0.7396432,0.00003105481,0.0006317511,0.0007289224,0.002025084,0.00002650924,0.01911651,0.00009325524,0.000011639,0.002904858],"study_design_scores_gemma":[0.1142339,0.1437904,0.7335388,0.00003584915,0.000282284,0.0001232189,0.001960003,0.001335336,0.001657586,0.002571682,0.0001613146,0.0003095952],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959523,0.001648148,0.0000114616,0.0001170957,0.0001382738,0.001754644,0.0001226861,0.00001355103,0.0002418588],"genre_scores_gemma":[0.9985629,0.00007939377,0.00008888969,0.00008234063,0.00003821515,0.0002672114,0.00005034405,0.00001632966,0.0008143423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1289399,"threshold_uncertainty_score":0.4269513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05119346624889778,"score_gpt":0.3405371055012791,"score_spread":0.2893436392523814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}