{"id":"W4224313646","doi":"10.3390/curroncol29040208","title":"Developments in the Management of Metastatic HER2-Positive Breast Cancer: A Review","year":2022,"lang":"en","type":"review","venue":"Current Oncology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Pertuzumab; Medicine; Trastuzumab; Trastuzumab emtansine; Human Epidermal Growth Factor Receptor 2; Metastatic breast cancer; Oncology; Breast cancer; Lapatinib; Cancer; Systemic therapy; Antibody-drug conjugate; Internal medicine; Hormone receptor; Disease; Antibody; Immunology; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003887969,0.0007029448,0.0009280599,0.002329,0.000265067,0.0008025981,0.000676185,0.0007307513,0.003920566],"category_scores_gemma":[0.0005828989,0.0001762631,0.0004532596,0.002185978,0.0002826742,0.001042064,0.0004796375,0.001442033,0.001950776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005042682,"about_ca_system_score_gemma":0.0009405491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00129439,"about_ca_topic_score_gemma":0.003141226,"domain_scores_codex":[0.9998615,0.00002391055,0.00002242348,0.00002240645,0.00005665769,0.00001313854],"domain_scores_gemma":[0.9997656,0.0001021845,0.0000391687,0.000004804671,0.00006308472,0.0000251888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004057752,0.00006118865,0.0001131162,0.01820016,0.00005135176,0.0001889574,0.00005945393,0.0002493821,0.0007968216,0.001646353,0.03381697,0.9447758],"study_design_scores_gemma":[0.00001263926,0.0001047473,0.000692985,0.00702611,0.0001008297,0.001523622,0.00007557144,0.00006873021,0.0001854889,0.0009538023,0.9892405,0.00001507973],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007366538,0.9986518,0.00006688453,0.0002200984,0.0001771575,0.000004342477,0.00001234493,0.000005699614,0.0007880664],"genre_scores_gemma":[0.0002516045,0.9990898,0.0001161161,0.0001237751,0.000115351,0.000003189604,0.00001621754,8.396177e-7,0.0002830914],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003920566,"threshold_uncertainty_score":0.01311558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.427164784705476,"score_gpt":0.5917821791165028,"score_spread":0.1646173944110268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}