{"id":"W4224313646","doi":"10.3390/curroncol29040208","title":"Developments in the Management of Metastatic HER2-Positive Breast Cancer: A Review","year":2022,"lang":"en","type":"review","venue":"Current Oncology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Pertuzumab; Medicine; Trastuzumab; Trastuzumab emtansine; Human Epidermal Growth Factor Receptor 2; Metastatic breast cancer; Oncology; Breast cancer; Lapatinib; Cancer; Systemic therapy; Antibody-drug conjugate; Internal medicine; Hormone receptor; Disease; Antibody; Immunology; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002109368,0.0003677602,0.002619921,0.0002910554,0.00005456999,0.00000610671,0.0007158995,0.00008304657,0.00198328],"category_scores_gemma":[0.0000401207,0.0002390379,0.0003713074,0.00134369,0.0001416939,0.00002152267,0.0004273974,0.001292304,0.00006067717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002623443,"about_ca_system_score_gemma":0.002656305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006630135,"about_ca_topic_score_gemma":0.00002358526,"domain_scores_codex":[0.9954352,0.001552304,0.00112675,0.0005261872,0.0008716231,0.0004879473],"domain_scores_gemma":[0.9983284,0.0004114951,0.0005043113,0.0005552273,0.00009665472,0.0001038439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001615596,0.0005302079,0.00002630365,0.2299619,0.0004576544,0.0003064211,0.0001218972,4.056434e-8,4.5527e-9,0.000108577,0.006696363,0.7617745],"study_design_scores_gemma":[0.0004619147,0.0001818259,0.0001461752,0.1440466,0.002382111,0.0004209147,0.00009290675,3.211148e-7,3.22269e-8,0.000005933694,0.8521112,0.0001500534],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[9.867226e-7,0.9866342,0.000002361242,0.0007476102,0.0007004326,0.005223113,0.0002853087,0.00001057418,0.006395415],"genre_scores_gemma":[0.000001538961,0.9924566,0.0001617856,0.0003085011,0.000075147,0.006438415,0.0003444499,0.00004377103,0.0001698312],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8454148,"threshold_uncertainty_score":0.998929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.427164784705476,"score_gpt":0.5917821791165028,"score_spread":0.1646173944110268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}