{"id":"W4224316732","doi":"10.3389/fcell.2022.867138","title":"Pharmacokinetics, Mass Balance, Excretion, and Tissue Distribution of Plasmalogen Precursor PPI-1011","year":2022,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Phenomenome Discoveries (Canada)","funders":"","keywords":"Pharmacokinetics; Adipose tissue; In vivo; Excretion; Chemistry; Urine; Distribution (mathematics); Internal medicine; Endocrinology; Oral administration; Lean body mass; Pharmacology; Biology; Body weight; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001527441,0.0002993066,0.0003961505,0.0002717325,0.000131741,0.0003348,0.000148613,0.000379649,0.0008213358],"category_scores_gemma":[0.0003260802,0.0002312351,0.0002054781,0.000179348,0.0002878461,0.0003553165,0.00007959639,0.0006618327,0.0002610633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003521862,"about_ca_system_score_gemma":0.000347583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001398141,"about_ca_topic_score_gemma":0.001355419,"domain_scores_codex":[0.9999075,0.00002405029,0.000004154992,0.00002188701,0.00002484304,0.00001761642],"domain_scores_gemma":[0.9998394,0.00004178536,0.00004350949,0.0000187139,0.00002281615,0.00003381914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005055401,0.0003093994,0.005428523,0.00008825992,0.00005117659,0.0001875343,0.00008460574,0.000964664,0.9630927,0.00008495177,0.0001870864,0.02446567],"study_design_scores_gemma":[0.0002009806,0.02191879,0.1046819,0.00001520039,0.0002001375,0.001086571,0.0002497064,0.007723168,0.8596752,0.0001663406,0.004017695,0.00006425872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99718,0.0008926016,0.001105362,0.00003341497,0.000005350787,0.00002117521,0.0002298553,0.00004676122,0.0004855715],"genre_scores_gemma":[0.9952257,0.001026666,0.001154357,0.00004604033,0.000008927973,0.00004774734,0.0004890937,0.00002258076,0.001979019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001398141,"threshold_uncertainty_score":0.00278002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004669127284317639,"score_gpt":0.2108974436278923,"score_spread":0.2062283163435746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}