{"id":"W4224317226","doi":"10.1021/acsmedchemlett.2c00027","title":"SiRNAs with Neutral Phosphate Triester Hydrocarbon Tails Exhibit Carrier-Free Gene-Silencing Activity","year":2022,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Tech University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Gene silencing; Phosphate; Hydrocarbon; Chemistry; Gene; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002597987,0.0004444831,0.0002718258,0.0001426968,0.000137877,0.0003128129,0.000129047,0.0003795919,0.000798146],"category_scores_gemma":[0.0002929569,0.0001827151,0.0002345579,0.0001428843,0.0003333614,0.0002899772,0.000240312,0.0003718056,0.0004709375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001656604,"about_ca_system_score_gemma":0.000204985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00019794,"about_ca_topic_score_gemma":0.0005061564,"domain_scores_codex":[0.9998432,0.00003848472,0.00001826909,0.00002666181,0.00005193196,0.00002135336],"domain_scores_gemma":[0.999724,0.00009256547,0.00008686886,0.00002793086,0.00003791232,0.00003073168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002258666,0.00000372748,0.0000425355,0.00002242601,0.00000344589,0.00002413129,0.000005839081,0.0000555112,0.9992924,0.00004407711,0.000008618451,0.0004747303],"study_design_scores_gemma":[0.000003120544,0.000116799,0.0003591307,0.000001181015,0.000006405757,0.00007048078,0.000002599335,0.0001971144,0.9987282,0.00002026564,0.0004923149,0.00000246389],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823683,0.00209644,0.01185753,0.0001412429,0.00002350811,0.00007178322,0.0002260239,0.0001770134,0.003038171],"genre_scores_gemma":[0.9896912,0.001072658,0.006391142,0.00009989554,0.00001151863,0.0000465514,0.000349504,0.00003484043,0.002302678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000798146,"threshold_uncertainty_score":0.00267005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007199938010197943,"score_gpt":0.2051746795180838,"score_spread":0.1979747415078859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}