{"id":"W4224317226","doi":"10.1021/acsmedchemlett.2c00027","title":"SiRNAs with Neutral Phosphate Triester Hydrocarbon Tails Exhibit Carrier-Free Gene-Silencing Activity","year":2022,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Tech University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Gene silencing; Phosphate; Hydrocarbon; Chemistry; Gene; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002137936,0.0003305362,0.0002719698,0.00002991134,0.0002474597,0.00003123173,0.0006348099,0.0001027511,0.0001032342],"category_scores_gemma":[0.00003136273,0.0003100372,0.0001118304,0.0001442804,0.0001903114,0.0000138693,0.0003506862,0.0004402212,0.000002606874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009247499,"about_ca_system_score_gemma":0.0001503627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001357837,"about_ca_topic_score_gemma":0.00001366811,"domain_scores_codex":[0.9981058,0.00005745011,0.0002394214,0.0006528911,0.0004226211,0.0005218124],"domain_scores_gemma":[0.9988191,0.00001842264,0.0001666388,0.0007627924,0.00004760882,0.0001854682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006248011,0.00004334094,0.001063589,0.00003916115,0.0001095301,0.0001774941,0.0001999739,0.0004758332,0.9914434,4.906751e-7,0.00536957,0.0004528149],"study_design_scores_gemma":[0.001260184,0.0003597874,0.0003375211,0.00002602757,0.00007398521,0.0003058274,0.0004408228,0.00003160715,0.9935724,0.000006990995,0.003196094,0.000388713],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965166,0.0004548823,0.0002220506,0.001749363,0.0002091135,0.0001464522,0.00005329851,0.00002955037,0.0006186754],"genre_scores_gemma":[0.9952955,0.0000407749,0.00004945536,0.003219712,0.0005640335,0.00008471049,0.0001421759,0.00004279319,0.0005608202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002173475,"threshold_uncertainty_score":0.9999352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007199938010197943,"score_gpt":0.2051746795180838,"score_spread":0.1979747415078859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}