{"id":"W4224320666","doi":"10.3390/cells11091442","title":"Differential Sensitivity of the Protein Translation Initiation Machinery and mTOR Signaling to MECP2 Gain- and Loss-of-Function Involves MeCP2 Isoform-Specific Homeostasis in the Brain","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Ontario Rett Syndrome Association; University of Manitoba","keywords":"MECP2; Biology; Gene isoform; Cell biology; Translation (biology); Protein kinase B; Signal transduction; Messenger RNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002441537,0.00007400358,0.00007483186,0.00003759376,0.00008533309,0.000009887388,0.00006194528,0.00002997003,0.000008074548],"category_scores_gemma":[0.0000148179,0.00005593627,0.00002880939,0.0001011972,0.00003979392,0.000003069614,0.00009367653,0.00006226504,9.304168e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004988156,"about_ca_system_score_gemma":0.00001594702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001538283,"about_ca_topic_score_gemma":0.00004319416,"domain_scores_codex":[0.999302,0.0002021249,0.0001421321,0.0001553754,0.0001197164,0.00007867887],"domain_scores_gemma":[0.9997667,0.0000286219,0.00006183101,0.0001126041,0.00001527784,0.00001495779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008414916,0.00003966195,0.001019017,0.000029487,0.000007054109,2.938642e-7,0.0006697245,0.0002143525,0.9938585,0.00002211728,0.00004799925,0.004007671],"study_design_scores_gemma":[0.0004513964,0.0002201438,0.07147443,0.00001261374,0.00001032099,0.000002402098,0.0006866031,0.0002778649,0.925838,0.0002339386,0.0006865875,0.0001057256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977227,0.000290669,0.001164825,0.0003380698,0.00005659184,0.0003677386,0.00003397314,0.000001320363,0.0000241238],"genre_scores_gemma":[0.9996067,0.00006347282,0.00009092059,0.0001576865,0.000009062785,0.000020013,0.00003591695,0.000007118091,0.000009151699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07045541,"threshold_uncertainty_score":0.2281015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01460632533799161,"score_gpt":0.2120282016277034,"score_spread":0.1974218762897118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}