{"id":"W4224325436","doi":"10.3390/pharmaceutics14050905","title":"Inclusion of a Phytomedicinal Flavonoid in Biocompatible Surface-Modified Chylomicron Mimic Nanovesicles with Improved Oral Bioavailability and Virucidal Activity: Molecular Modeling and Pharmacodynamic Studies","year":2022,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Pharmacological Effects of Natural Compounds","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Fisheries and Oceans Canada; Memorial University of Newfoundland","funders":"","keywords":"Bioavailability; Chemistry; Permeation; Pharmacology; Pharmacokinetics; First pass effect; Chromatography; Ex vivo; In vitro; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001477805,0.0002031196,0.0001547253,0.0001273779,0.00005588466,0.0001394765,0.0001489363,0.0001992937,0.0003501784],"category_scores_gemma":[0.000121851,0.00007293122,0.0002812535,0.0000962754,0.00008159057,0.0001856666,0.00008326038,0.0001599619,0.0001011205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002254965,"about_ca_system_score_gemma":0.00009205822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001035769,"about_ca_topic_score_gemma":0.0007159697,"domain_scores_codex":[0.999953,0.000005940277,0.000003707393,0.00001259719,0.00001506102,0.000009737071],"domain_scores_gemma":[0.9999642,0.000009358896,0.00001166936,0.000002420911,0.000007424595,0.000004876037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00006571234,0.00002039457,0.0001053552,0.0000319615,0.000005287373,0.00002783754,0.0000109912,0.0009493169,0.9973118,0.00006185124,0.00001715129,0.001392309],"study_design_scores_gemma":[0.00001185379,0.0004553374,0.00136191,0.000003626952,0.00002421064,0.00004383249,0.00001224476,0.01561159,0.9816847,0.00002300719,0.0007598317,0.000007866523],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960168,0.0005395592,0.002973456,0.000020416,0.000006202253,0.00002141591,0.0001113931,0.00003147974,0.0002792702],"genre_scores_gemma":[0.9947348,0.0005576338,0.003957462,0.00001012244,0.000002807393,0.00002350104,0.0001170544,0.000009710334,0.0005870272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001035769,"threshold_uncertainty_score":0.00205946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.11664493782462,"score_gpt":0.4437458294663222,"score_spread":0.3271008916417022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}