{"id":"W4224325436","doi":"10.3390/pharmaceutics14050905","title":"Inclusion of a Phytomedicinal Flavonoid in Biocompatible Surface-Modified Chylomicron Mimic Nanovesicles with Improved Oral Bioavailability and Virucidal Activity: Molecular Modeling and Pharmacodynamic Studies","year":2022,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Pharmacological Effects of Natural Compounds","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Fisheries and Oceans Canada; Memorial University of Newfoundland","funders":"","keywords":"Bioavailability; Chemistry; Permeation; Pharmacology; Pharmacokinetics; First pass effect; Chromatography; Ex vivo; In vitro; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00221356,0.0005581107,0.0009247448,0.0003289772,0.0007455569,0.000020077,0.0004372646,0.0001849219,0.00008887551],"category_scores_gemma":[0.00007042268,0.0004977594,0.00009027874,0.0007420966,0.0008231491,0.0002794666,0.002290591,0.002088838,0.000001262552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004606561,"about_ca_system_score_gemma":0.0001589586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001410137,"about_ca_topic_score_gemma":0.00004426716,"domain_scores_codex":[0.9958566,0.001463679,0.0006447581,0.0008296325,0.00043897,0.0007663416],"domain_scores_gemma":[0.9981898,0.0007603901,0.0003531257,0.0002263618,0.0001541112,0.0003162172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.005619601,0.0008016928,0.00296624,0.0004520019,0.0003871204,0.00009280526,0.001057693,0.04150265,0.9312869,0.00002592736,0.00002492399,0.01578245],"study_design_scores_gemma":[0.007345548,0.0006800827,0.0003265887,0.00002966096,0.0003433668,0.00004503611,0.0002808828,0.6042229,0.3856336,0.0003493361,0.000307186,0.0004358993],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845964,0.01200542,0.000161762,0.001079734,0.0004069699,0.001460306,0.0001311419,0.0001067759,0.00005151838],"genre_scores_gemma":[0.9962437,0.001523474,0.0007030756,0.001299845,0.00004106103,0.0001027185,0.00001743405,0.00005027015,0.00001838385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5627202,"threshold_uncertainty_score":0.9997474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.11664493782462,"score_gpt":0.4437458294663222,"score_spread":0.3271008916417022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}