{"id":"W4224325508","doi":"10.1111/jth.15740","title":"von Willebrand factor propeptide variants lead to impaired storage and ER retention in patient‐derived endothelial colony‐forming cells","year":2022,"lang":"en","type":"article","venue":"Journal of Thrombosis and Haemostasis","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Impact; Queen's University","funders":"National Heart, Lung, and Blood Institute; Canadian Hemophilia Society","keywords":"Von Willebrand factor; Von Willebrand disease; Protein precursor; Phenotype; Molecular biology; Genotype; Endoplasmic reticulum; Chemistry; Biology; Immunology; Genetics; Gene; Platelet","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002082372,0.0003530661,0.0002863906,0.0002192246,0.0001674029,0.0004801684,0.000352088,0.0006651423,0.002866049],"category_scores_gemma":[0.0006342204,0.0001489433,0.0003249212,0.0002540503,0.0002554829,0.0001917804,0.0002247324,0.0007769298,0.0005525987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000138987,"about_ca_system_score_gemma":0.0001247416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005544131,"about_ca_topic_score_gemma":0.0002782617,"domain_scores_codex":[0.9997119,0.00007450576,0.00004550022,0.00004411934,0.00007411662,0.00004977236],"domain_scores_gemma":[0.9997224,0.0001144102,0.00005756656,0.00004512336,0.00002314709,0.0000373415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001307564,0.0004032347,0.003299288,0.00004804776,0.0001009523,0.00767808,0.0002135506,0.000666419,0.9796382,0.0009859472,0.0007439286,0.004914827],"study_design_scores_gemma":[0.0006117546,0.002891956,0.05281447,0.00002642292,0.0002839418,0.05317916,0.0003876214,0.01048999,0.8695388,0.000865879,0.008848891,0.00006102584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982398,0.0001554583,0.0006302401,0.00009431208,0.00002189719,0.00001319027,0.0003328579,0.00003171466,0.0004806924],"genre_scores_gemma":[0.9986672,0.00006621169,0.000303867,0.00004407996,0.00000591815,0.000005710268,0.0003380897,0.00001477353,0.0005541966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002866049,"threshold_uncertainty_score":0.009587944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03909313418100773,"score_gpt":0.2796063551455691,"score_spread":0.2405132209645613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}