{"id":"W4224437476","doi":"10.1021/acs.biochem.2c00064","title":"Phosphonate and α-Fluorophosphonate Analogues of <scp>d</scp>-Glucose 6-Phosphate as Active-Site Probes of 1<scp>l</scp>-<i>myo</i>-Inositol 1-Phosphate Synthase","year":2022,"lang":"en","type":"article","venue":"Biochemistry","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Active site; Chemistry; Phosphonate; Stereochemistry; ATP synthase; Moiety; Ternary complex; Enzyme; NAD+ kinase; Substrate (aquarium); Docking (animal); Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001698394,0.0004023208,0.0001790599,0.0001699691,0.0001228867,0.0001396626,0.0003583097,0.0004168536,0.001157783],"category_scores_gemma":[0.0001380192,0.0001432872,0.0001446098,0.0001830134,0.0001950341,0.0002156375,0.0001326959,0.0004402196,0.0002732299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002324879,"about_ca_system_score_gemma":0.0001740227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008705631,"about_ca_topic_score_gemma":0.00111467,"domain_scores_codex":[0.9998643,0.00003025129,0.000009857112,0.00002783092,0.00003123354,0.00003644345],"domain_scores_gemma":[0.9999281,0.00001695453,0.00002105407,0.000007281283,0.00001171487,0.00001489066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002781127,0.00003333187,0.00006422883,0.00006152,0.000005601511,0.00009109113,0.00002234248,0.0002861823,0.9960062,0.0002243642,0.00006834183,0.002858704],"study_design_scores_gemma":[0.00003107811,0.0003908646,0.0003701987,0.000003456257,0.000006269183,0.0001305891,0.000008773452,0.0003357225,0.9962474,0.00001981677,0.002449851,0.000006002566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838081,0.00325184,0.005466455,0.0001414113,0.00005967045,0.0001033027,0.0005540235,0.00009054555,0.006524563],"genre_scores_gemma":[0.9884702,0.002641596,0.005593507,0.0001291353,0.0000185417,0.00006036233,0.000618143,0.00002084897,0.002447662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001157783,"threshold_uncertainty_score":0.003873169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0110970620249536,"score_gpt":0.2594260561365077,"score_spread":0.248328994111554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}