{"id":"W4224491653","doi":"10.1016/j.jbc.2022.101983","title":"microRNA-27b regulates hepatic lipase enzyme LIPC and reduces triglyceride degradation during hepatitis C virus infection","year":2022,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research","keywords":"microRNA; Lipid metabolism; Hepatitis C virus; Lipid droplet; Triglyceride; Intracellular; Adipose triglyceride lipase; Enzyme; Chemistry; Serine; Cell biology; Biology; Fold change; Microarray; Molecular biology; Biochemistry; Downregulation and upregulation; Virus; Lipase; Gene expression; Cholesterol; Gene; Virology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001960424,0.0002417433,0.0003348572,0.0002325793,0.000158707,0.0002748784,0.0001369704,0.000205178,0.001214681],"category_scores_gemma":[0.0002360408,0.0001568535,0.0002491209,0.000124079,0.0002817591,0.0001249549,0.0002229893,0.0004490224,0.0005746637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002927381,"about_ca_system_score_gemma":0.0003595247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005654751,"about_ca_topic_score_gemma":0.0006739913,"domain_scores_codex":[0.9998276,0.00004014941,0.00001668978,0.00003030475,0.00004631847,0.00003882992],"domain_scores_gemma":[0.9999101,0.00001230412,0.00001674964,0.000008882706,0.00002209457,0.00002978669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003995593,0.00003086969,0.0002358285,0.00002746639,0.000004907575,0.00004338677,0.00001201227,0.00005271392,0.9976366,0.00006899526,0.00007818091,0.001409565],"study_design_scores_gemma":[0.00004744866,0.0004684507,0.01036984,0.000008999242,0.00002346005,0.0002546461,0.0000538263,0.001781306,0.9839689,0.00008259827,0.002930989,0.000009599607],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881114,0.004124471,0.003531924,0.0002626571,0.0001102164,0.00005308276,0.0003595541,0.0001736465,0.003272988],"genre_scores_gemma":[0.9930332,0.001224765,0.002175358,0.0001500336,0.00001637106,0.00006360613,0.0004157783,0.00005630823,0.002864548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001214681,"threshold_uncertainty_score":0.004063547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01081349089774995,"score_gpt":0.2317733698066713,"score_spread":0.2209598789089214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}