{"id":"W4224657289","doi":"10.1002/cpt.2620","title":"Exposure‐Response Modeling and Simulation to Support Human Dosing of Botulism Antitoxin Heptavalent Product","year":2022,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Botulinum Toxin and Related Neurological Disorders","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emergent BioSolutions (Canada)","funders":"","keywords":"Antitoxin; Botulism; Botulinum neurotoxin; Potency; Dosing; Neurotoxin; Serotype; Medicine; Neutralization; Toxin; Botulinum toxin; Pharmacology; Immunology; Biology; Antibody; Anesthesia; Microbiology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008964579,0.0007038762,0.0008144823,0.0003951532,0.0003061675,0.0007543874,0.000862436,0.001487789,0.003430442],"category_scores_gemma":[0.00284564,0.0004666149,0.0009414824,0.0003236098,0.000275245,0.0004089343,0.0004112172,0.001025641,0.0003752393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001068551,"about_ca_system_score_gemma":0.001586516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02148556,"about_ca_topic_score_gemma":0.007950174,"domain_scores_codex":[0.9996803,0.0001462912,0.00001402601,0.00004215525,0.00006214736,0.000055164],"domain_scores_gemma":[0.9980546,0.001450388,0.0001538356,0.00004516415,0.0002349589,0.00006103859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00007845906,0.00004770587,0.0008538387,0.00001807617,0.00001787551,0.00003839699,0.00001164867,0.9970011,0.000367564,0.0003877458,0.0001341622,0.001043379],"study_design_scores_gemma":[0.00001418513,0.00004530315,0.0002090753,0.000002746728,0.000007403065,0.000007481193,0.000005950993,0.9990596,0.0002037057,0.0002191001,0.0002219069,0.00000351062],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7999821,0.0008801813,0.1702021,0.001267112,0.0001617174,0.0004838555,0.001697006,0.0007890571,0.02453681],"genre_scores_gemma":[0.9846706,0.0002282649,0.01065406,0.0001268026,0.00001367992,0.0002126428,0.0003725703,0.00004731408,0.003673961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02148556,"threshold_uncertainty_score":0.04272103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1406764614512664,"score_gpt":0.451465372009939,"score_spread":0.3107889105586725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}