{"id":"W4224674578","doi":"10.1002/cam4.4778","title":"Germline mutations in penetrant cancer predisposition genes are rare in men with prostate cancer selecting active surveillance","year":2022,"lang":"en","type":"article","venue":"Cancer Medicine","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institutes of Health; Canary Foundation; Congressionally Directed Medical Research Programs; National Cancer Institute; Prostate Cancer Foundation","keywords":"Germline; Germline mutation; Prostate cancer; Genetics; Cancer; Biology; Gene; Medicine; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003521795,0.000294907,0.0006292889,0.0004603407,0.0002358257,0.00001060605,0.0001330288,0.00005871754,0.001316074],"category_scores_gemma":[0.00003412591,0.0002195335,0.00004082582,0.001704892,0.0001900833,0.0001442577,0.00005974747,0.0006768514,0.000001003788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00252881,"about_ca_system_score_gemma":0.001133604,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.01334543,"about_ca_topic_score_gemma":0.02076597,"domain_scores_codex":[0.9974191,0.0001658019,0.000429343,0.0006212706,0.0007346716,0.0006297968],"domain_scores_gemma":[0.9989917,0.0001057821,0.0002214557,0.0002280946,0.0002708272,0.0001820911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00680432,0.0002446872,0.9392045,0.0004166428,0.0002135707,0.0006272595,0.008587619,0.008473842,0.009388929,0.00000425421,0.001243829,0.02479055],"study_design_scores_gemma":[0.0162161,0.0009373377,0.9624817,0.001830651,0.000136342,0.00005537985,0.008058315,0.0030494,0.004559607,0.00003169287,0.002280038,0.0003634591],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9448238,0.03469294,0.000007729906,0.01709026,0.0002415214,0.002009062,0.0004791996,0.00006112919,0.0005943619],"genre_scores_gemma":[0.9817217,0.009055741,0.00002454849,0.0004198936,0.0004147024,0.005850179,0.0003865004,0.00006089935,0.002065816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03689792,"threshold_uncertainty_score":0.9995968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02316113072098295,"score_gpt":0.3390496907150577,"score_spread":0.3158885599940748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}