{"id":"W4224674578","doi":"10.1002/cam4.4778","title":"Germline mutations in penetrant cancer predisposition genes are rare in men with prostate cancer selecting active surveillance","year":2022,"lang":"en","type":"article","venue":"Cancer Medicine","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institutes of Health; Canary Foundation; Congressionally Directed Medical Research Programs; National Cancer Institute; Prostate Cancer Foundation","keywords":"Germline; Germline mutation; Prostate cancer; Genetics; Cancer; Biology; Gene; Medicine; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005767511,0.0001963039,0.0003246184,0.0005403218,0.0003467187,0.0005640427,0.0003167161,0.0003673562,0.001906289],"category_scores_gemma":[0.003064684,0.0002134846,0.000243412,0.0005527805,0.0003863421,0.0003151138,0.0002932157,0.0003913791,0.0001168389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001079929,"about_ca_system_score_gemma":0.0002299093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001141858,"about_ca_topic_score_gemma":0.001807775,"domain_scores_codex":[0.9994583,0.0001440962,0.00003454209,0.0001500038,0.000132917,0.00008007928],"domain_scores_gemma":[0.9982831,0.0004717685,0.000839386,0.0001106691,0.00009150124,0.0002035864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001046626,0.00001521505,0.9972942,0.000009441437,0.00002656116,0.0001724801,0.00003787822,0.00004102171,0.0003818619,0.00002313266,0.00004510758,0.00184835],"study_design_scores_gemma":[0.000009324299,0.0001859126,0.9964567,0.000007331251,0.0000592738,0.002336295,0.0001470453,0.0002695191,0.0002249959,0.0001023497,0.0001975967,0.00000368571],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999247,0.0002929347,0.000123394,0.00002449927,0.000003103457,0.000004576235,0.00006125879,0.000004558577,0.0002386601],"genre_scores_gemma":[0.9998035,0.00006284541,0.00003757173,0.000008054906,0.000006453587,0.000001225428,0.00004944413,0.000001009836,0.00002995176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001906289,"threshold_uncertainty_score":0.006377101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02316113072098295,"score_gpt":0.3390496907150577,"score_spread":0.3158885599940748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}