{"id":"W4224720970","doi":"10.3389/fonc.2022.860767","title":"Intra-Tumoral CD8+ T-Cell Infiltration and PD-L1 Positivity in Homologous Recombination Deficient Pancreatic Ductal Adenocarcinoma","year":2022,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Ontario Institute for Cancer Research; McGill Genome Centre; McGill University; McGill University Health Centre","funders":"Terry Fox Research Institute; Invitae; Pancreatic Cancer Canada Foundation; Government of Ontario","keywords":"Pancreatic ductal adenocarcinoma; CD8; Infiltration (HVAC); Cancer research; Homologous recombination; Homologous chromosome; Adenocarcinoma; Cell; Medicine; Pancreatic cancer; Pathology; Biology; Internal medicine; Antigen; Immunology; Gene; Genetics; Materials science; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001710245,0.0001528099,0.0001648264,0.0005052559,0.00009957817,0.0001947793,0.0001057095,0.0001926771,0.0009939361],"category_scores_gemma":[0.0001723394,0.0001552467,0.000105353,0.0002064778,0.0001881376,0.0001667416,0.0001944555,0.0002279209,0.0001494655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001207571,"about_ca_system_score_gemma":0.00004908282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001621586,"about_ca_topic_score_gemma":0.0002079747,"domain_scores_codex":[0.9998934,0.00001760005,0.00001789659,0.00003162446,0.00002095472,0.00001846059],"domain_scores_gemma":[0.9998504,0.00002515631,0.00004649855,0.00001594207,0.00000835283,0.00005366931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002115773,0.0001909939,0.0982887,0.0001128337,0.00004108798,0.002467727,0.0001468167,0.0001652441,0.8892068,0.00007805245,0.00009507706,0.007090831],"study_design_scores_gemma":[0.00007517133,0.001628774,0.8690929,0.00001636808,0.00006397662,0.01926663,0.0003958545,0.001914325,0.1056359,0.0001310764,0.001767002,0.00001208071],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991365,0.0002386216,0.0002201943,0.000005499517,0.000001655504,0.000004813669,0.00004262058,0.00001130641,0.0003387256],"genre_scores_gemma":[0.9992829,0.0001025098,0.0002870015,0.000007647513,0.000001973181,0.000008484753,0.00006753751,0.000002079084,0.0002399185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009939361,"threshold_uncertainty_score":0.003325045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01561634755654923,"score_gpt":0.2888899327131569,"score_spread":0.2732735851566077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}