{"id":"W4224720970","doi":"10.3389/fonc.2022.860767","title":"Intra-Tumoral CD8+ T-Cell Infiltration and PD-L1 Positivity in Homologous Recombination Deficient Pancreatic Ductal Adenocarcinoma","year":2022,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Ontario Institute for Cancer Research; McGill Genome Centre; McGill University; McGill University Health Centre","funders":"Terry Fox Research Institute; Invitae; Pancreatic Cancer Canada Foundation; Government of Ontario","keywords":"Pancreatic ductal adenocarcinoma; CD8; Infiltration (HVAC); Cancer research; Homologous recombination; Homologous chromosome; Adenocarcinoma; Cell; Medicine; Pancreatic cancer; Pathology; Biology; Internal medicine; Antigen; Immunology; Gene; Genetics; Materials science; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001256448,0.0001657632,0.0007205094,0.0006403127,0.0001584209,0.00001029583,0.0001203914,0.0001875035,0.0001575316],"category_scores_gemma":[0.0002267647,0.0001758678,0.00004603413,0.0005071894,0.0002697239,0.00008729045,0.0001472151,0.0007959344,0.000006095322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001785412,"about_ca_system_score_gemma":0.0006395812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003768106,"about_ca_topic_score_gemma":0.0001610503,"domain_scores_codex":[0.9975257,0.0008294035,0.0004596985,0.0004325163,0.0002762926,0.0004764231],"domain_scores_gemma":[0.9992392,0.0002491925,0.000131759,0.0002078949,0.00005065345,0.0001212881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001045025,0.001106595,0.9863906,0.00006079192,0.00002932944,0.001191555,0.001621985,0.00003502482,0.001179239,0.0002655739,0.002958231,0.004116078],"study_design_scores_gemma":[0.005624068,0.004289465,0.9752212,0.00002116944,0.0001069487,0.0008864796,0.003306415,0.007565287,0.0001325402,0.002086752,0.0005930617,0.000166596],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863212,0.001715753,0.0005041572,0.002189274,0.0006494555,0.000933215,0.00001098058,0.00002634211,0.007649607],"genre_scores_gemma":[0.9935715,0.0002443952,0.004771686,0.0004023285,0.00005037039,0.000316033,0.00008950156,0.00001767511,0.0005365335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01116935,"threshold_uncertainty_score":0.717168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01561634755654923,"score_gpt":0.2888899327131569,"score_spread":0.2732735851566077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}