{"id":"W4224857498","doi":"10.1158/2767-9764.crc-22-0037","title":"Repurposing Itraconazole and Hydroxychloroquine to Target Lysosomal Homeostasis in Epithelial Ovarian Cancer","year":2022,"lang":"en","type":"article","venue":"Cancer Research Communications","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital; Princess Margaret Cancer Centre; University Health Network","funders":"Government of Ontario","keywords":"Hydroxychloroquine; Repurposing; Itraconazole; Drug repositioning; Ovarian cancer; Cancer; Homeostasis; Medicine; Cancer research; Internal medicine; Pharmacology; Biology; Drug; Coronavirus disease 2019 (COVID-19); Dermatology; Disease; Antifungal","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002843493,0.0001437628,0.0004047469,0.0002748839,0.0001202392,0.0003636734,0.0001994545,0.0002007255,0.0006939085],"category_scores_gemma":[0.0001637666,0.00009659192,0.0003151745,0.0002446248,0.0001482801,0.0001538626,0.0002165901,0.0004682984,0.0001291643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003686251,"about_ca_system_score_gemma":0.000299606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007246552,"about_ca_topic_score_gemma":0.003566735,"domain_scores_codex":[0.9998815,0.00003249874,0.000010522,0.00001722774,0.00002868612,0.00002949111],"domain_scores_gemma":[0.9999162,0.0000153841,0.00001768492,0.00001541415,0.00001680552,0.00001856997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001062628,0.0004878342,0.003519211,0.0003526064,0.00008843698,0.0002959186,0.00006930875,0.001951892,0.9206681,0.0002386569,0.0007026521,0.0705628],"study_design_scores_gemma":[0.001707367,0.01949707,0.05877606,0.0001383936,0.0003418775,0.003590957,0.0002794242,0.007144605,0.8671297,0.0007439469,0.04060737,0.0000431843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764884,0.0181664,0.001802874,0.0004130543,0.00003963209,0.0002258769,0.0003678427,0.0001061392,0.002389876],"genre_scores_gemma":[0.9936624,0.003935769,0.001250926,0.0001407625,0.00001117404,0.00004702317,0.0004164175,0.000009640418,0.0005258842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007246552,"threshold_uncertainty_score":0.00267458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05911338055807427,"score_gpt":0.4076690462993662,"score_spread":0.3485556657412919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}