{"id":"W4224862222","doi":"10.21203/rs.3.rs-1554912/v1","title":"The Association of FKBP5 Gene Methylation, Adolescents’ Sex, and Depressive Symptoms among Chinese Adolescents: A Nested Case-Control Study","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Adolescent and Pediatric Healthcare","field":"Health Professions","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"FKBP5; DNA methylation; Methylation; Medicine; Longitudinal study; Case-control study; CpG site; Depressive symptoms; Nested case-control study; Clinical psychology; Internal medicine; Psychiatry; Genetics; Gene; Biology; Glucocorticoid receptor; Cognition; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001130558,0.0004247878,0.0005032619,0.0007053549,0.001158291,0.0004913215,0.0006037652,0.0004492677,0.0007609588],"category_scores_gemma":[0.001194089,0.0005891597,0.0006904299,0.0007259965,0.0004987222,0.0002177088,0.0003753754,0.0003361394,0.00009147926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006185009,"about_ca_system_score_gemma":0.0007063874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02108187,"about_ca_topic_score_gemma":0.02534581,"domain_scores_codex":[0.9992099,0.0001495562,0.0001017231,0.0003174352,0.0001360397,0.00008530766],"domain_scores_gemma":[0.9993963,0.00007275665,0.0001790303,0.0001391367,0.0001081443,0.0001045266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001531139,0.00006747149,0.997851,0.00001748645,0.0001379562,0.0001892862,0.0002303992,0.00001675034,0.000668735,0.00002710726,0.00005321333,0.0005874773],"study_design_scores_gemma":[0.00004307467,0.0001935954,0.9982942,0.000009411518,0.0002197555,0.0003602537,0.0002040842,0.0002530707,0.0001693778,0.00002365794,0.0002250284,0.000004528115],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999477,0.0001385195,0.0001435744,0.00001305782,0.00000384479,0.00003253093,0.0001011154,0.000001587527,0.0000887067],"genre_scores_gemma":[0.9994272,0.00006296122,0.0001695646,0.00002560204,0.000004754264,0.00003911819,0.0001752908,0.00000101541,0.00009443183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02108187,"threshold_uncertainty_score":0.04191834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05325069067114067,"score_gpt":0.4590829446945324,"score_spread":0.4058322540233917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}