{"id":"W4224923085","doi":"10.1002/oby.23400","title":"Early metabolic impairment as a contributor to neurodegenerative disease: Mechanisms and potential pharmacological intervention","year":2022,"lang":"en","type":"review","venue":"Obesity","topic":"Cardiovascular Disease and Adiposity","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"American University of Beirut","keywords":"Metabolic syndrome; Medicine; Insulin resistance; Pathogenesis; Endothelial dysfunction; Bioinformatics; Inflammation; Context (archaeology); Neuroinflammation; Neuroscience; Internal medicine; Endocrinology; Diabetes mellitus; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003473894,0.0007156296,0.00124914,0.001856431,0.0002519529,0.0008097722,0.0007075267,0.0008731252,0.004292449],"category_scores_gemma":[0.0004102916,0.0002047364,0.0005925193,0.00127354,0.0003093427,0.0008276484,0.0005944048,0.001504828,0.001519618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004380247,"about_ca_system_score_gemma":0.000785108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007470374,"about_ca_topic_score_gemma":0.001853826,"domain_scores_codex":[0.9998893,0.00002206976,0.00001954888,0.0000187413,0.00003540108,0.00001496648],"domain_scores_gemma":[0.9998735,0.00005572059,0.00001913763,0.000004465911,0.00003453348,0.0000124684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001702681,0.0001597878,0.0002118641,0.03304901,0.0001883557,0.0004192877,0.00007945046,0.0003686061,0.003095162,0.004889982,0.02642646,0.9309418],"study_design_scores_gemma":[0.00004228434,0.000193412,0.001304989,0.008236602,0.000244718,0.002142884,0.00007863465,0.0001323013,0.0006805586,0.002837268,0.9840823,0.00002407722],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001298314,0.9986947,0.00009034929,0.0001779722,0.0001374806,0.00000428986,0.00001736832,0.000005695962,0.0007422814],"genre_scores_gemma":[0.0005642865,0.9986659,0.0001406448,0.0001122502,0.00008836573,0.00000587146,0.00002549524,0.000001028145,0.0003960655],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004292449,"threshold_uncertainty_score":0.01435971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0203814898266544,"score_gpt":0.3174210328983409,"score_spread":0.2970395430716866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}