{"id":"W4224923085","doi":"10.1002/oby.23400","title":"Early metabolic impairment as a contributor to neurodegenerative disease: Mechanisms and potential pharmacological intervention","year":2022,"lang":"en","type":"review","venue":"Obesity","topic":"Cardiovascular Disease and Adiposity","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"American University of Beirut","keywords":"Metabolic syndrome; Medicine; Insulin resistance; Pathogenesis; Endothelial dysfunction; Bioinformatics; Inflammation; Context (archaeology); Neuroinflammation; Neuroscience; Internal medicine; Endocrinology; Diabetes mellitus; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003650237,0.0003910188,0.00158964,0.0001817233,0.0002146962,0.00006132368,0.0001374024,0.0001169241,0.001064633],"category_scores_gemma":[0.00006852164,0.0003179352,0.001822302,0.0002839468,0.00003195197,0.00005297059,0.0004637919,0.0004485826,0.00006106703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001033939,"about_ca_system_score_gemma":0.0001721042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002305352,"about_ca_topic_score_gemma":4.003885e-7,"domain_scores_codex":[0.9974435,0.0007029782,0.0003590327,0.0006927333,0.0004929528,0.0003087762],"domain_scores_gemma":[0.9986733,0.00003427384,0.0001285444,0.0003273597,0.00003557298,0.0008009593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000739,0.002182103,0.00007679702,0.00595825,0.005654741,0.003583973,0.00004432787,0.000002901186,0.00006137427,0.001309732,0.0006830998,0.9797037],"study_design_scores_gemma":[0.001673849,0.0006423729,0.007901026,0.0009475885,0.03163509,0.0002044384,0.000006805903,0.000008692553,0.00003172802,0.0000672507,0.956451,0.0004301651],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01330915,0.9823111,0.0006537043,0.00007407235,0.0004157466,0.002676724,0.0004323813,0.00008300898,0.00004408944],"genre_scores_gemma":[0.005333369,0.9921911,0.00006663566,0.0003205813,0.0003334382,0.0005060135,0.0004405467,0.00003852832,0.0007697872],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9792736,"threshold_uncertainty_score":0.9999273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0203814898266544,"score_gpt":0.3174210328983409,"score_spread":0.2970395430716866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}