{"id":"W4224924566","doi":"10.1016/j.tranon.2022.101434","title":"AGO-RBP crosstalk on target mRNAs: Implications in miRNA-guided gene silencing and cancer","year":2022,"lang":"en","type":"review","venue":"Translational Oncology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"Argonaute; Gene silencing; microRNA; Biology; RNA-binding protein; Untranslated region; Translation (biology); Computational biology; Crosstalk; Three prime untranslated region; Messenger RNA; Regulation of gene expression; Dicer; Gene; RNA interference; Genetics; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003418592,0.0002548926,0.0006209503,0.0001838696,0.0001634759,0.00001769593,0.0002404542,0.0003277222,0.0003138719],"category_scores_gemma":[0.00004991765,0.0002425633,0.0001850302,0.0002016847,0.00009530219,0.000004566859,0.00006782835,0.0004110339,0.000006479259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001661598,"about_ca_system_score_gemma":0.001263709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001410502,"about_ca_topic_score_gemma":0.0002871947,"domain_scores_codex":[0.9981887,0.0002408217,0.0004931123,0.000550283,0.000176821,0.000350267],"domain_scores_gemma":[0.9992729,0.0001725238,0.0001538626,0.0002469485,0.00004014909,0.0001136581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008026809,0.0001736139,0.0002237198,0.000925223,0.0002037838,0.00002924733,0.0001074058,0.0004517669,0.009460185,0.0005553449,0.001046963,0.9867425],"study_design_scores_gemma":[0.000497694,0.0002339342,0.0003163391,0.0001604255,0.00004838765,0.00005424056,0.00001090846,0.00002915853,0.0001171968,0.000113248,0.9981837,0.0002348194],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.008082262,0.9890023,0.0001059751,0.0005271373,0.0001154238,0.0006297477,0.0004237163,0.00000903605,0.001104407],"genre_scores_gemma":[0.0008729724,0.9953536,0.0005475213,0.0002325861,0.0002282283,0.000658911,0.001307143,0.00004187491,0.0007570957],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9971367,"threshold_uncertainty_score":0.9891445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1042187278232981,"score_gpt":0.4352683057966557,"score_spread":0.3310495779733576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}