{"id":"W4224930894","doi":"10.1101/2022.01.26.22269888","title":"Germline TYK2 mutation and cancer risk","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Medical Research Council","keywords":"Medicine; Lung cancer; Internal medicine; Oncology; Prostate cancer; Cancer; Genome-wide association study; Lymphoma; Genotype; Biology; Single-nucleotide polymorphism; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002090325,0.0001607103,0.0002822609,0.0001381329,0.000116879,0.00002389737,0.00006183063,0.00009088088,0.003745453],"category_scores_gemma":[0.0001452145,0.0001458164,0.000111776,0.00008612195,0.00003433373,0.00002383311,0.000219055,0.0009129964,0.00001329258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009834977,"about_ca_system_score_gemma":0.0001438004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001000327,"about_ca_topic_score_gemma":0.00005950922,"domain_scores_codex":[0.9989944,0.00005800064,0.0002509407,0.0003557294,0.0002100835,0.0001308486],"domain_scores_gemma":[0.9992718,0.00006233295,0.0001919116,0.0002967211,0.0000854691,0.00009175135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002831226,0.0004528888,0.9124363,0.0008466007,0.0008460006,0.0005586217,0.002700356,0.003460275,0.02756322,0.0002281781,0.008378882,0.04224556],"study_design_scores_gemma":[0.0019023,0.0004517342,0.6920092,0.0007048991,0.001401778,0.0002721739,0.0003449674,0.01224577,0.01027878,0.001168029,0.2785641,0.0006563081],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992947,0.002234713,0.0002647528,0.001198426,0.001135198,0.00031484,0.0001896256,0.0000885018,0.001626947],"genre_scores_gemma":[0.9949188,0.001845848,0.000422374,0.0002613291,0.0005497077,0.0001978189,0.0002174569,0.00003585307,0.001550854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2701852,"threshold_uncertainty_score":0.9971653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03133542323398241,"score_gpt":0.3312075252865426,"score_spread":0.2998721020525602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}