{"id":"W4224930894","doi":"10.1101/2022.01.26.22269888","title":"Germline TYK2 mutation and cancer risk","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Medical Research Council","keywords":"Medicine; Lung cancer; Internal medicine; Oncology; Prostate cancer; Cancer; Genome-wide association study; Lymphoma; Genotype; Biology; Single-nucleotide polymorphism; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004626706,0.0002941486,0.0003915501,0.000591141,0.0002217988,0.0004589448,0.00023752,0.0004596922,0.004849619],"category_scores_gemma":[0.002424549,0.0001696909,0.0007656902,0.001084862,0.0001936588,0.0001792018,0.0002218213,0.0004855782,0.00030514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002103164,"about_ca_system_score_gemma":0.0001517377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003506835,"about_ca_topic_score_gemma":0.002198326,"domain_scores_codex":[0.9995162,0.0001109779,0.00003825605,0.0002146634,0.00007335169,0.00004642635],"domain_scores_gemma":[0.9988587,0.0004476953,0.0003826669,0.00009876941,0.00009240521,0.0001197204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001609185,0.00003494925,0.9855424,0.0001183558,0.001418696,0.000500756,0.00003143968,0.0004272606,0.00302078,0.0001423488,0.0008687879,0.006284995],"study_design_scores_gemma":[0.0001552935,0.0003127442,0.9902297,0.00005850265,0.001490287,0.002415108,0.00004929012,0.001269825,0.001480624,0.0005240042,0.001997917,0.00001674557],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871633,0.006311848,0.0009683185,0.0002666118,0.00007139017,0.00002025304,0.003374162,0.00005636601,0.001767703],"genre_scores_gemma":[0.9982139,0.0004677356,0.0002058922,0.00004836833,0.00003586294,0.00001077103,0.0006292168,0.000007813246,0.0003805248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004849619,"threshold_uncertainty_score":0.01622355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03133542323398241,"score_gpt":0.3312075252865426,"score_spread":0.2998721020525602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}