{"id":"W4224938505","doi":"10.1016/j.bbrc.2022.04.113","title":"Enhanced proteolytic resistance of cationic antimicrobial peptides through lysine side chain analogs and cyclization","year":2022,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Cystic Fibrosis Canada","keywords":"Trypsin; Peptide; Chemistry; Biochemistry; Proteolytic enzymes; Hemolysis; Lysine; Enzyme; Antimicrobial peptides; Antimicrobial; Amino acid; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002341544,0.0002881907,0.000191666,0.0001069923,0.0001167526,0.0002470576,0.0002671209,0.0003330873,0.00190407],"category_scores_gemma":[0.0003401374,0.0001150335,0.0002405,0.0001010707,0.000223196,0.0002407179,0.0002109565,0.0004522399,0.0003071627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001937914,"about_ca_system_score_gemma":0.0001529552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002449272,"about_ca_topic_score_gemma":0.0002310601,"domain_scores_codex":[0.9998319,0.00004182843,0.00001561413,0.00003052716,0.00002458465,0.00005551035],"domain_scores_gemma":[0.9997839,0.00006033819,0.00005750475,0.00003192235,0.00002424452,0.00004213076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003612774,0.00004938903,0.00009481749,0.00003344629,0.000007687599,0.0001153093,0.00002496194,0.0002313155,0.9975044,0.0001670242,0.00003202525,0.001378275],"study_design_scores_gemma":[0.00002911032,0.0004953468,0.0004328877,0.000003229132,0.000005869713,0.0001522468,0.00001040388,0.0004372069,0.997731,0.00002136816,0.0006742334,0.00000709356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997901,0.0003090803,0.0007703406,0.00003919193,0.00001586638,0.00002254285,0.0000399629,0.00002661996,0.0008753713],"genre_scores_gemma":[0.9985533,0.0001054077,0.000532222,0.00002800278,0.000004716276,0.00001026641,0.00005410907,0.000009459969,0.0007024091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00190407,"threshold_uncertainty_score":0.00636977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04030904903752949,"score_gpt":0.3167355674707253,"score_spread":0.2764265184331959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}