{"id":"W4224950223","doi":"10.1038/s41467-022-29963-5","title":"ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Mitacs; Canadian Institutes of Health Research; Terry Fox Research Institute; National Cancer Institute; Government of Canada; Prostate Cancer Foundation","keywords":"Epigenetics; Biology; Chromatin remodeling; Chromatin; Transcription factor; Bivalent chromatin; Phenotype; Lineage (genetic); Histone; Cancer research; Neuroendocrine differentiation; Cell biology; Prostate cancer; Genetics; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002288062,0.000104516,0.0001781888,0.00007174433,0.0003723348,0.00001306622,0.000585726,0.0000610753,0.00003855036],"category_scores_gemma":[0.00001825792,0.00007220246,0.00007898956,0.00069477,0.00009765393,0.00007110023,0.0006346185,0.001499336,7.154252e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001658271,"about_ca_system_score_gemma":0.0003400537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001638942,"about_ca_topic_score_gemma":0.0002131344,"domain_scores_codex":[0.9988369,0.0002050719,0.0002419443,0.0001668485,0.0003450878,0.0002041948],"domain_scores_gemma":[0.9985892,0.0001528842,0.0001269559,0.0009919888,0.0001070703,0.000031909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001928281,0.006179065,0.710355,0.001256122,0.0005265971,0.00003567056,0.05394806,0.007947153,0.1316283,0.001632391,0.01073548,0.07382791],"study_design_scores_gemma":[0.01585221,0.001190168,0.201613,0.001415976,0.0004938645,0.00008704877,0.02021445,0.04665622,0.1103811,0.0002738594,0.6008129,0.001009197],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9517096,0.03194851,0.000002861246,0.01275702,0.0001626598,0.001376679,0.00009462833,0.00004699122,0.001901083],"genre_scores_gemma":[0.9948065,0.002026564,0.001205183,0.0002548568,0.00002262506,0.0004675363,0.0001032473,0.00002174764,0.001091778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5900774,"threshold_uncertainty_score":0.6513951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03573191031250478,"score_gpt":0.3452550057430522,"score_spread":0.3095230954305474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}