{"id":"W4224954015","doi":"10.1101/2022.01.29.478231","title":"Reduction in cardiolipin reduces expression of creatine transporter-1 and creatine transport in hBMEC/D3 human brain microvessel endothelial cells","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital Research Institute of Manitoba; University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Cardiolipin; Biology; Gene knockdown; Creatine; Metabolite; Mitochondrion; Microvessel; Biochemistry; Molecular biology; Phospholipid; Angiogenesis; Apoptosis; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001325166,0.0002370713,0.0002743749,0.0002149957,0.0001632295,0.0003062437,0.0001792439,0.0003202104,0.001352255],"category_scores_gemma":[0.0001183835,0.0001326285,0.0002504173,0.0002614098,0.0001704185,0.0001172896,0.0001191109,0.0005102842,0.0003892044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004164645,"about_ca_system_score_gemma":0.0001972501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003886401,"about_ca_topic_score_gemma":0.00319737,"domain_scores_codex":[0.9998465,0.00001924676,0.00001926821,0.00003280457,0.00004575722,0.00003634877],"domain_scores_gemma":[0.9998804,0.00001733612,0.00003781133,0.00001313032,0.00002427661,0.00002704272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006992288,0.00001800663,0.0001362221,0.00001904672,0.000005483866,0.00002582089,0.00001135348,0.00002527042,0.9992113,0.00003440253,0.00006968318,0.0003734027],"study_design_scores_gemma":[0.00003082991,0.0002344103,0.007775701,0.00000566761,0.00003052739,0.0002007838,0.00005138817,0.0009929129,0.9880508,0.00002787818,0.002593573,0.00000544884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939529,0.001280329,0.001971313,0.0001827029,0.00003719766,0.00002381926,0.001631263,0.0001535731,0.0007668324],"genre_scores_gemma":[0.9933868,0.0006161138,0.001538153,0.00009005467,0.000004691609,0.00004374289,0.001613201,0.00002536838,0.002681907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003886401,"threshold_uncertainty_score":0.007727563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01022685223582476,"score_gpt":0.2284044580113836,"score_spread":0.2181776057755589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}