{"id":"W4224980576","doi":"10.1016/j.msard.2022.103829","title":"The metabolic potential of the paediatric-onset multiple sclerosis gut microbiome","year":2022,"lang":"en","type":"article","venue":"Multiple Sclerosis and Related Disorders","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; University of Toronto; SickKids Foundation; University of Saskatchewan; Simon Fraser University; University of Manitoba; Saskatchewan Disease Control Laboratory; Public Health Agency of Canada; Hospital for Sick Children; University of British Columbia","funders":"Janssen Canada; Canadian Institutes of Health Research; Institute for Translational Neuroscience; National Institutes of Health; Crohn's and Colitis Canada; Multiple Sclerosis Society of Canada; University of Manitoba; Emerald Publishing; Multiple Sclerosis Scientific Research Foundation; Takeda Canada; Immune Tolerance Network; Public Health Agency of Canada; Biogen; Patient-Centered Outcomes Research Institute; American Academy of Neurology; U.S. Department of Defense; Genome Canada; Novartis; Erasmus Medisch Centrum; National Multiple Sclerosis Society; Pfizer Canada; Alexion Pharmaceuticals; Roche; University of British Columbia","keywords":"Multiple sclerosis; Interquartile range; Medicine; Microbiome; Internal medicine; Feces; Physiology; Immunology; Gastroenterology; Biology; Bioinformatics; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.0004083614,0.0002256669,0.0002211317,0.00006152098,0.001572222,0.00003875695,0.0004579494,0.000162025,0.0000413303],"category_scores_gemma":[0.00009123487,0.0001500665,0.0002898368,0.0003798887,0.0003369471,0.000005845458,0.0006224225,0.000311808,0.000003857929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001684214,"about_ca_system_score_gemma":0.00009298669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003574471,"about_ca_topic_score_gemma":0.0003202565,"domain_scores_codex":[0.9982211,0.0003024277,0.0004302141,0.0004235632,0.0001872235,0.0004354495],"domain_scores_gemma":[0.9990395,0.00005824606,0.0002500474,0.0005132656,0.00005250325,0.00008641162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001447301,0.0001827422,0.0278897,0.00001514564,0.0001586959,1.691776e-7,0.0002241211,0.0006613765,0.9590452,0.00002043452,0.004323761,0.007333913],"study_design_scores_gemma":[0.006061778,0.0003296148,0.8482121,0.00003107608,0.0002239577,0.00002709194,0.001966171,0.0008234399,0.02513569,0.00009108263,0.116491,0.000606992],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800274,0.01699888,0.00001762348,0.001327565,0.0007302735,0.0005137061,0.0003040896,0.00001654527,0.00006389079],"genre_scores_gemma":[0.9860551,0.01303719,0.00006177767,0.0002287983,0.00003970555,0.00005792115,0.0001138037,0.00003670838,0.0003689378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9339095,"threshold_uncertainty_score":0.9997276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01046993406264786,"score_gpt":0.1968629729903071,"score_spread":0.1863930389276593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}