{"id":"W4224980576","doi":"10.1016/j.msard.2022.103829","title":"The metabolic potential of the paediatric-onset multiple sclerosis gut microbiome","year":2022,"lang":"en","type":"article","venue":"Multiple Sclerosis and Related Disorders","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; University of Toronto; SickKids Foundation; University of Saskatchewan; Simon Fraser University; University of Manitoba; Saskatchewan Disease Control Laboratory; Public Health Agency of Canada; Hospital for Sick Children; University of British Columbia","funders":"Janssen Canada; Canadian Institutes of Health Research; Institute for Translational Neuroscience; National Institutes of Health; Crohn's and Colitis Canada; Multiple Sclerosis Society of Canada; University of Manitoba; Emerald Publishing; Multiple Sclerosis Scientific Research Foundation; Takeda Canada; Immune Tolerance Network; Public Health Agency of Canada; Biogen; Patient-Centered Outcomes Research Institute; American Academy of Neurology; U.S. Department of Defense; Genome Canada; Novartis; Erasmus Medisch Centrum; National Multiple Sclerosis Society; Pfizer Canada; Alexion Pharmaceuticals; Roche; University of British Columbia","keywords":"Multiple sclerosis; Interquartile range; Medicine; Microbiome; Internal medicine; Feces; Physiology; Immunology; Gastroenterology; Biology; Bioinformatics; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004018252,0.000241599,0.0003122581,0.0004364614,0.0002603745,0.001148107,0.0001596177,0.0006057795,0.0008273165],"category_scores_gemma":[0.001196998,0.0001715449,0.000237881,0.0003837898,0.0004088468,0.000618464,0.0008271837,0.000629857,0.0001120592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003339202,"about_ca_system_score_gemma":0.0003637633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007625187,"about_ca_topic_score_gemma":0.0009693751,"domain_scores_codex":[0.9996212,0.0001665729,0.00001576865,0.00005361312,0.00006531212,0.00007758048],"domain_scores_gemma":[0.9996504,0.00008558962,0.0001213866,0.00002488364,0.00004489614,0.00007278354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003027436,0.0001413627,0.3694815,0.0008250842,0.0004761764,0.004129365,0.001617194,0.001803458,0.4776791,0.01415267,0.001623141,0.1250436],"study_design_scores_gemma":[0.00005822705,0.0009141974,0.9171208,0.000500384,0.0002700706,0.01060135,0.002167276,0.002741812,0.02792571,0.01300068,0.02462942,0.0000702351],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9698638,0.02349465,0.001887387,0.001455231,0.0001005537,0.000008048824,0.0004190952,0.00001867055,0.002752654],"genre_scores_gemma":[0.9931337,0.005366252,0.0009223602,0.0001103967,0.00004943391,0.000006962432,0.0001051957,0.000005289646,0.0003003345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001148107,"threshold_uncertainty_score":0.002767622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01046993406264786,"score_gpt":0.1968629729903071,"score_spread":0.1863930389276593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}