{"id":"W4224981192","doi":"10.1038/s41541-022-00461-5","title":"Two DNA vaccines protect against severe disease and pathology due to SARS-CoV-2 in Syrian hamsters","year":2022,"lang":"en","type":"article","venue":"npj Vaccines","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; McMaster University; University of Toronto; University of Saskatchewan; Université Laval; University of Alberta; University of Guelph; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"University of Toronto; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Immunogenicity; DNA vaccination; Virology; Vaccination; Hamster; Pandemic; Immune system; Medicine; Antibody; Immunology; Titer; Infectious disease (medical specialty); Mesocricetus; Biology; Virus; Disease; Antibody titer; Coronavirus disease 2019 (COVID-19); Immunization; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005231707,0.0003277354,0.000576339,0.0006352645,0.000220794,0.00005011164,0.0003026898,0.00007376161,0.00003421261],"category_scores_gemma":[0.0004506057,0.0002951118,0.0001122052,0.000853224,0.00002776839,0.0001277414,0.0005358423,0.0004917583,0.00004638566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001877063,"about_ca_system_score_gemma":0.0002930996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002682048,"about_ca_topic_score_gemma":0.0004969091,"domain_scores_codex":[0.9974846,0.0002549589,0.0004193325,0.0007586537,0.0004297257,0.0006527347],"domain_scores_gemma":[0.9989436,0.0001245553,0.00007539715,0.0006242086,0.0001049111,0.0001273687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00493112,0.000597024,0.4775012,0.0005798917,0.0001079775,0.008346228,0.001539108,0.00002190039,0.4732479,0.00009167476,0.006196988,0.026839],"study_design_scores_gemma":[0.03015619,0.003702616,0.6403855,0.0005619581,0.0003013131,0.002618994,0.002906612,0.001802077,0.1454946,0.002310294,0.1675723,0.002187502],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906321,0.0006703652,0.00001740524,0.005588897,0.0002412591,0.001804836,0.0000457285,0.000127026,0.0008723869],"genre_scores_gemma":[0.9468535,0.00000750142,0.0001250592,0.05175487,0.0002731702,0.0008000666,0.00001525603,0.00006450248,0.000106045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3277533,"threshold_uncertainty_score":0.9999501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03014297558391166,"score_gpt":0.3290683224323128,"score_spread":0.2989253468484011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}