{"id":"W4224981192","doi":"10.1038/s41541-022-00461-5","title":"Two DNA vaccines protect against severe disease and pathology due to SARS-CoV-2 in Syrian hamsters","year":2022,"lang":"en","type":"article","venue":"npj Vaccines","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; McMaster University; University of Toronto; University of Saskatchewan; Université Laval; University of Alberta; University of Guelph; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"University of Toronto; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Immunogenicity; DNA vaccination; Virology; Vaccination; Hamster; Pandemic; Immune system; Medicine; Antibody; Immunology; Titer; Infectious disease (medical specialty); Mesocricetus; Biology; Virus; Disease; Antibody titer; Coronavirus disease 2019 (COVID-19); Immunization; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002282482,0.0005851664,0.000617058,0.0006204386,0.0001357324,0.0003017183,0.0002313096,0.0006268821,0.0008838699],"category_scores_gemma":[0.0002231051,0.0001737723,0.000297108,0.0001658663,0.0003573225,0.0002317801,0.0002225899,0.0005023123,0.0002007422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004203708,"about_ca_system_score_gemma":0.0003500025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003325875,"about_ca_topic_score_gemma":0.0004638853,"domain_scores_codex":[0.9998487,0.00001873053,0.00001621447,0.0000364402,0.00003284829,0.00004698824],"domain_scores_gemma":[0.9998747,0.00001659005,0.00004248855,0.00001088453,0.00001881908,0.00003656892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004176604,0.0002879927,0.0003783019,0.00006791997,0.00001859645,0.00004748289,0.00002148467,0.0002173315,0.9949792,0.0001042681,0.00004263115,0.003417143],"study_design_scores_gemma":[0.0005866216,0.01820274,0.009266363,0.00003424605,0.0001134612,0.0002957183,0.00004483384,0.00140918,0.9666553,0.0001663976,0.003206282,0.00001877791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974349,0.0006446869,0.00105533,0.00006708221,0.00005075573,0.00006599604,0.0001610826,0.00005131387,0.0004687906],"genre_scores_gemma":[0.9940227,0.0006167383,0.002015569,0.0001026998,0.00002946901,0.0001070388,0.0007788846,0.00001545569,0.002311401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008838699,"threshold_uncertainty_score":0.003050089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03014297558391166,"score_gpt":0.3290683224323128,"score_spread":0.2989253468484011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}