{"id":"W4224981558","doi":"10.1136/bmjopen-2021-053012","title":"Comparative safety and efficacy of cognitive enhancers for Alzheimer’s dementia: a systematic review with individual patient data network meta-analysis","year":2022,"lang":"en","type":"review","venue":"BMJ Open","topic":"Neuroethics, Human Enhancement, Biomedical Innovations","field":"Neuroscience","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; University of Toronto; University of Calgary; University of Alberta; St. Michael's Hospital","funders":"Canadian Institutes of Health Research; Eisai; H. Lundbeck A/S; Yale University; GlaxoSmithKline","keywords":"Donepezil; Medicine; Galantamine; Rivastigmine; Dementia; Meta-analysis; Memantine; Placebo; Adverse effect; Randomized controlled trial; Internal medicine; Cochrane Library; Disease; Alternative medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04064757,0.003430654,0.02327129,0.008656519,0.0007210968,0.00386672,0.002561039,0.00265556,0.004333094],"category_scores_gemma":[0.08988256,0.001828502,0.0438565,0.006650843,0.001162326,0.003071786,0.002302509,0.002011257,0.0003891204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003984436,"about_ca_system_score_gemma":0.003899663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003924486,"about_ca_topic_score_gemma":0.008416801,"domain_scores_codex":[0.9549401,0.02918427,0.008947087,0.002897523,0.003505581,0.0005253772],"domain_scores_gemma":[0.9503934,0.03738649,0.007730478,0.001617397,0.002494104,0.0003781829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00310287,0.00003110885,0.001742775,0.2519222,0.7365506,0.0000594476,0.00006215818,0.0004491658,0.0001280951,0.0001358667,0.00027382,0.005541845],"study_design_scores_gemma":[0.00251173,0.0003343305,0.001451245,0.02030077,0.9735877,0.00006266392,0.0000368096,0.0003015851,0.0001017485,0.0003088457,0.0009779626,0.00002452495],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01358692,0.9752666,0.00365309,0.0004524623,0.0004509134,0.004182623,0.001518021,0.00009151946,0.0007979696],"genre_scores_gemma":[0.4628881,0.4935218,0.01706133,0.002151304,0.0005774365,0.02040123,0.002433678,0.00009591716,0.0008691402],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.04064757,"threshold_uncertainty_score":0.2149674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.7222396849021508,"score_gpt":0.5422947880942708,"score_spread":0.1799448968078801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}