{"id":"W4224987195","doi":"10.1016/j.biopsych.2022.02.786","title":"P549. MRI Neuromelanin Accumulation in Patients with Treatment-Resistant Schizophrenia: A Cross-Sectional Pilot Study","year":2022,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Advanced MRI Techniques and Applications","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Royal Ottawa Mental Health Centre; University of Ottawa; University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Neuromelanin; Dopamine; Substantia nigra; Schizophrenia (object-oriented programming); Biomarker; Internal medicine; In vivo; Neuroscience; Psychosis; Medicine; Ventral tegmental area; Endocrinology; Chemistry; Dopaminergic; Psychology; Biology; Psychiatry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002965194,0.0004850196,0.0004264769,0.000408883,0.0007246648,0.0005299667,0.0002225205,0.0006243391,0.00237569],"category_scores_gemma":[0.0008165825,0.0004106796,0.0002773855,0.0002749914,0.0003800137,0.0005659668,0.0003157227,0.0006045933,0.000599309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002481241,"about_ca_system_score_gemma":0.0002456616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00235801,"about_ca_topic_score_gemma":0.002486187,"domain_scores_codex":[0.9998316,0.00004974073,0.00001348873,0.00004720618,0.000028845,0.00002915191],"domain_scores_gemma":[0.9995498,0.0000839326,0.0001529443,0.00003195615,0.00005761121,0.0001237851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005935201,0.002208754,0.965835,0.00006968452,0.0001636317,0.001363357,0.0007423293,0.00005111739,0.01818548,0.00004842809,0.0001518686,0.005245219],"study_design_scores_gemma":[0.0001747382,0.004748397,0.9918601,0.000006644261,0.0001088689,0.001522936,0.0006501179,0.0001197153,0.0005688379,0.00003362577,0.0001943919,0.00001167406],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995846,0.00008449314,0.0000468865,0.00001353155,0.000002868133,0.00001521288,0.00005416175,0.000001602102,0.0001966376],"genre_scores_gemma":[0.9994913,0.00006833341,0.00006558136,0.0000329534,0.00000568787,0.00001395168,0.00008651013,0.000001565322,0.0002341755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00237569,"threshold_uncertainty_score":0.007947505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0675374165123322,"score_gpt":0.3547333432977358,"score_spread":0.2871959267854036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}