{"id":"W4224998140","doi":"10.1172/jci.insight.159721","title":"Accelerated waning of immunity to SARS-CoV-2 mRNA vaccines in patients with immune-mediated inflammatory diseases","year":2022,"lang":"en","type":"article","venue":"JCI Insight","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Women's College Hospital; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; LEO Pharma; Bausch Health; Krembil Foundation; University of Toronto; Canadian Institutes of Health Research; Women's College Hospital; Ontario Genomics; Genome Canada; King's College London; Gilead Sciences; Pfizer; Royal Bank of Canada; Government of Ontario; L'Oreal USA; Sanofi; Amgen; Celgene; AstraZeneca; Eli Lilly and Company","keywords":"Medicine; Immunogenicity; Immunity; Immunology; Ankylosing spondylitis; Rheumatoid arthritis; Azathioprine; Immune system; Vaccination; Cohort; Disease; Psoriatic arthritis; Internal medicine; Gastroenterology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009120873,0.0003402623,0.0005490436,0.0004941007,0.0004306831,0.0006754739,0.000210108,0.0004387223,0.001773105],"category_scores_gemma":[0.002150587,0.0002019884,0.0004015224,0.0004871872,0.000261622,0.0004866765,0.0003120515,0.0006810137,0.0002324733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002319353,"about_ca_system_score_gemma":0.0002184088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006683335,"about_ca_topic_score_gemma":0.0005269242,"domain_scores_codex":[0.9994547,0.000137087,0.00005988997,0.0001505039,0.00006701744,0.0001308699],"domain_scores_gemma":[0.9978951,0.0003615129,0.001128088,0.0001462993,0.0001606593,0.0003082951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004302257,0.00004904851,0.996096,0.00001504151,0.00002575856,0.0001881838,0.00006891836,0.00002790375,0.0008801356,0.00001854039,0.000050259,0.002150111],"study_design_scores_gemma":[0.0000162903,0.0005310353,0.9981324,0.000006674313,0.00002726356,0.0006714279,0.00007542758,0.00008439647,0.0002054611,0.0000243248,0.0002223652,0.000002863057],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993325,0.0002416806,0.0000729681,0.000027329,0.000004304045,0.00000527258,0.00007262439,0.000003001408,0.000240246],"genre_scores_gemma":[0.9996494,0.00006437493,0.00004259686,0.00003315302,0.00001468488,0.000003909174,0.0001117383,0.000001139494,0.00007906503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001773105,"threshold_uncertainty_score":0.005931675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03072757344067999,"score_gpt":0.3032723113193583,"score_spread":0.2725447378786783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}