{"id":"W4224998140","doi":"10.1172/jci.insight.159721","title":"Accelerated waning of immunity to SARS-CoV-2 mRNA vaccines in patients with immune-mediated inflammatory diseases","year":2022,"lang":"en","type":"article","venue":"JCI Insight","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Women's College Hospital; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; LEO Pharma; Bausch Health; Krembil Foundation; University of Toronto; Canadian Institutes of Health Research; Women's College Hospital; Ontario Genomics; Genome Canada; King's College London; Gilead Sciences; Pfizer; Royal Bank of Canada; Government of Ontario; L'Oreal USA; Sanofi; Amgen; Celgene; AstraZeneca; Eli Lilly and Company","keywords":"Medicine; Immunogenicity; Immunity; Immunology; Ankylosing spondylitis; Rheumatoid arthritis; Azathioprine; Immune system; Vaccination; Cohort; Disease; Psoriatic arthritis; Internal medicine; Gastroenterology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002294615,0.0002390702,0.0005138623,0.000662673,0.0001725447,0.00002467206,0.0003461604,0.00006675558,0.00007220918],"category_scores_gemma":[0.0003280059,0.0001975018,0.00008287117,0.001513206,0.0000550164,0.0001812481,0.0004212833,0.0005379439,0.00003016196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002841819,"about_ca_system_score_gemma":0.0004794996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000677232,"about_ca_topic_score_gemma":0.0000838409,"domain_scores_codex":[0.9977057,0.0002017107,0.0005408713,0.0003318445,0.0007989922,0.0004208953],"domain_scores_gemma":[0.9987268,0.0001470502,0.0001514992,0.0005840105,0.0003351641,0.00005545498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003326288,0.00101676,0.8142638,0.0001241823,0.00009865447,0.0001102123,0.00140718,0.000008476127,0.1783343,0.00001344293,0.000331918,0.0009648417],"study_design_scores_gemma":[0.005577735,0.001166614,0.8231905,0.0001218965,0.00004027954,0.000003019637,0.0003095852,0.00009207121,0.1477266,0.00001218466,0.02151387,0.0002456165],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973142,0.0003581561,0.000002825293,0.0001137944,0.0001184834,0.0008960639,0.00004338385,0.00008374362,0.001069396],"genre_scores_gemma":[0.9938732,0.000002493423,0.00002631812,0.005744978,0.0000384214,0.0001643537,0.00008239198,0.0000500842,0.0000178007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03060771,"threshold_uncertainty_score":0.8053891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03072757344067999,"score_gpt":0.3032723113193583,"score_spread":0.2725447378786783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}