{"id":"W4225000221","doi":"10.2217/epi-2021-0343","title":"DNA Methylation Profile of Liver Tissue in End-Stage Cholestatic Liver Disease","year":2022,"lang":"en","type":"article","venue":"Epigenomics","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health","keywords":"Biology; DNA methylation; Methylation; Liver disease; Liver tissue; Stage (stratigraphy); DNA; Cancer research; Genetics; Gene; Endocrinology; Biochemistry; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001435009,0.0001114239,0.0002118267,0.0001249912,0.00006258337,0.000005975791,0.0000689056,0.00001882532,0.003010688],"category_scores_gemma":[0.00002632172,0.0001108065,0.00007388095,0.0001479414,0.00003266482,0.00005431342,0.00008276015,0.00009667011,0.00005439263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003042621,"about_ca_system_score_gemma":0.0001889616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003737561,"about_ca_topic_score_gemma":0.00003134538,"domain_scores_codex":[0.9990728,0.00008436394,0.0002365432,0.0002242051,0.0002187035,0.0001634231],"domain_scores_gemma":[0.9994019,0.00006996517,0.00009777717,0.0002519637,0.00002969109,0.000148693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002694168,0.01314429,0.8083706,0.001795459,0.0006670986,0.005322263,0.01588971,0.003635964,0.01114036,0.008301402,0.00232895,0.1267097],"study_design_scores_gemma":[0.001643136,0.0002883683,0.9810734,0.00003119075,0.0002401973,0.000002433978,0.0002678525,0.001385623,0.006480208,0.0001007579,0.008343765,0.0001430296],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952682,0.002560232,0.00002984784,0.0001750325,0.00006715977,0.0008404013,0.0004899446,0.00001743727,0.0005516955],"genre_scores_gemma":[0.9974107,0.000341948,0.0004329732,0.0001603509,0.00003322969,0.0002059175,0.0004277076,0.00002198198,0.0009651829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1727028,"threshold_uncertainty_score":0.9979007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02295707614712143,"score_gpt":0.2737634735116481,"score_spread":0.2508063973645266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}