{"id":"W4225003254","doi":"10.1158/2326-6066.cir-21-0931","title":"Combination Neoantigen-Based Dendritic Cell Vaccination and Adoptive T-Cell Transfer Induces Antitumor Responses Against Recurrence of Hepatocellular Carcinoma","year":2022,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pancreas Centre (Canada)","funders":"","keywords":"Medicine; Immunotherapy; Adjuvant; CD8; Immune system; Immunology; T cell; Immunoediting; Hepatocellular carcinoma; Dendritic cell; Adjuvant therapy; Adoptive cell transfer; Oncology; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00211903,0.0002748402,0.0004834484,0.0009659768,0.001180628,0.00002663065,0.0006374909,0.0002672547,0.00117181],"category_scores_gemma":[0.0001394108,0.0002929153,0.0001167714,0.0008513902,0.0008659369,0.0001698446,0.0002298834,0.001404397,0.00003450865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002596536,"about_ca_system_score_gemma":0.000970547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000338989,"about_ca_topic_score_gemma":0.000006335692,"domain_scores_codex":[0.9934838,0.004453774,0.0005420955,0.0005737855,0.0002064431,0.0007400676],"domain_scores_gemma":[0.9977191,0.001097008,0.0001456328,0.0004904285,0.0005212529,0.00002657215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004561329,0.0006790746,0.0133865,0.0001062393,0.0001104939,0.00002480087,0.001698194,0.00001842873,0.9716684,0.0002582632,0.0002324744,0.007255764],"study_design_scores_gemma":[0.004691189,0.001890026,0.04202418,0.00004585392,0.00003197625,0.00003010429,0.002567635,0.0001062509,0.9423493,0.00006483858,0.005894388,0.0003042804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8980857,0.0996035,0.00008426097,0.0003375906,0.0006293074,0.0007684522,0.0001563548,0.00003800724,0.0002967894],"genre_scores_gemma":[0.9941695,0.003111415,0.00001474805,0.00007992505,0.00001070329,0.0004694072,0.000184997,0.00004030872,0.001919003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09649209,"threshold_uncertainty_score":0.9999523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0460332441837773,"score_gpt":0.3094296325806096,"score_spread":0.2633963883968323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}