{"id":"W4225006761","doi":"10.1126/science.abi6378","title":"Cancer cells use self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress","year":2022,"lang":"en","type":"article","venue":"Science","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stem Cell Network","funders":"Novo Nordisk Fonden","keywords":"DNA damage; CTCF; Chromatin; Cancer cell; Biology; DNA; Nuclease; DNA repair; Cancer; Cancer research; Mitosis; Genetics; Cell biology; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001319039,0.0003359051,0.0002937093,0.0002516965,0.0001991438,0.0005721592,0.00024017,0.0004643938,0.001066274],"category_scores_gemma":[0.000144692,0.0001440641,0.0001856652,0.0001527379,0.0003022565,0.0004173436,0.0004032689,0.0004903911,0.0004942778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002501183,"about_ca_system_score_gemma":0.0001662019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001694235,"about_ca_topic_score_gemma":0.0004295554,"domain_scores_codex":[0.9998716,0.00001517066,0.000008224541,0.00004597459,0.00003646885,0.00002248457],"domain_scores_gemma":[0.9998794,0.00001258927,0.00003938229,0.00003004874,0.00001537596,0.00002327214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001552472,0.000007403897,0.0003960263,0.00001865069,0.000003455955,0.00002729875,0.000009746617,0.00008575973,0.9978729,0.0002512461,0.00001438907,0.001297562],"study_design_scores_gemma":[0.000004863149,0.0001940971,0.005005223,0.00000599267,0.000006637558,0.0004686417,0.00003949101,0.0006079864,0.9907159,0.0002008471,0.002745181,0.000005176084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735249,0.005088614,0.01757357,0.0001465839,0.00003299703,0.0000438535,0.0002191854,0.0002555666,0.003114839],"genre_scores_gemma":[0.9941718,0.0009260404,0.0029923,0.00005257375,0.000005814188,0.00001318853,0.0001759617,0.00001763803,0.001644758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001066274,"threshold_uncertainty_score":0.00356704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00805242475396827,"score_gpt":0.2431685340932964,"score_spread":0.2351161093393281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}