{"id":"W4225006761","doi":"10.1126/science.abi6378","title":"Cancer cells use self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress","year":2022,"lang":"en","type":"article","venue":"Science","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stem Cell Network","funders":"Novo Nordisk Fonden","keywords":"DNA damage; CTCF; Chromatin; Cancer cell; Biology; DNA; Nuclease; DNA repair; Cancer; Cancer research; Mitosis; Genetics; Cell biology; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003005879,0.0001507805,0.0001036321,0.00008061525,0.000363484,0.00008076146,0.0008168259,0.00005057605,0.00007493163],"category_scores_gemma":[0.00005592017,0.0001559094,0.00004841596,0.000619188,0.00009124355,0.00001431341,0.0005365926,0.0001032788,0.00001360281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001102737,"about_ca_system_score_gemma":0.0003279112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008830185,"about_ca_topic_score_gemma":0.00003314583,"domain_scores_codex":[0.9981344,0.00005960319,0.0001517755,0.0006731949,0.0004976178,0.0004833538],"domain_scores_gemma":[0.9990954,0.00001001909,0.00006782483,0.0004710589,0.0001195712,0.0002360671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001989835,0.00006556776,0.0003193866,0.00000473009,0.000009086201,0.000003555987,0.0001628819,0.0001434766,0.9966511,0.00001644495,0.002335453,0.0002684172],"study_design_scores_gemma":[0.0002004131,0.0002391035,0.0009176674,0.000003282416,0.000008395725,0.000005766808,0.00006694862,0.0001724958,0.9747563,0.000009021633,0.02340611,0.000214502],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983329,0.0001389887,0.0001105028,0.0001560477,0.0004073679,0.0003350069,0.0002802841,0.00005529623,0.0001835656],"genre_scores_gemma":[0.9959927,0.00004129132,0.001029278,0.001268964,0.00006275696,0.0001302466,0.00002784216,0.00002246246,0.00142448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0218948,"threshold_uncertainty_score":0.6357799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00805242475396827,"score_gpt":0.2431685340932964,"score_spread":0.2351161093393281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}