{"id":"W4225012676","doi":"10.1128/mbio.00577-22","title":"Temsavir Treatment of HIV-1-Infected Cells Decreases Envelope Glycoprotein Recognition by Broadly Neutralizing Antibodies","year":2022,"lang":"en","type":"article","venue":"mBio","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Canada Foundation for Innovation; Canada Research Chairs; Government of Canada","keywords":"Glycoprotein; Virology; Antibody; Human immunodeficiency virus (HIV); Prodrug; Neutralizing antibody; Chemistry; Biology; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.00008020848,0.0001744704,0.0002717221,0.000110893,0.000340189,0.00001088465,0.0001071993,0.00006971659,0.002980456],"category_scores_gemma":[0.00001605697,0.0001507958,0.0001090312,0.0001520315,0.0001226421,0.00004936278,0.00006702971,0.0001084925,0.0009290072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001567701,"about_ca_system_score_gemma":0.00008181723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001533967,"about_ca_topic_score_gemma":0.00004286389,"domain_scores_codex":[0.9987671,0.0003088241,0.000231979,0.0002738353,0.00005636326,0.0003618387],"domain_scores_gemma":[0.9995208,0.0001023049,0.000095249,0.0002018583,0.00004201093,0.00003780963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004044906,0.001509025,0.00887742,0.00001743965,0.0003749032,0.00003890736,0.0004324176,0.000002315056,0.9385375,0.00001186655,0.01485769,0.034936],"study_design_scores_gemma":[0.002466635,0.001692417,0.003387178,0.00001356507,0.00005362939,0.00003834732,0.0002919526,6.170948e-7,0.8692284,0.00003001139,0.1226453,0.0001519524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915527,0.004421982,0.00001302585,0.0001543282,0.0001529087,0.0005291136,0.00208971,0.00007084487,0.001015369],"genre_scores_gemma":[0.9903471,0.000570698,0.00009793077,0.00002466943,0.00001144695,0.0002248423,0.004279431,0.00001677456,0.004427115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1077876,"threshold_uncertainty_score":0.9998489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02173748767263663,"score_gpt":0.2537261264620572,"score_spread":0.2319886387894206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}