{"id":"W4225013658","doi":"10.21203/rs.3.rs-1559637/v1","title":"Basal Gp78-dependent mitophagy promotes mitochondrial health and limits mitochondrial ROS","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University; University of British Columbia","funders":"University of British Columbia; Canadian Institutes of Health Research; Western Canada Research Grid; Compute Canada; Faculty of Medicine, University of British Columbia","keywords":"Mitophagy; Mitochondrion; Cell biology; Mitochondrial ROS; Basal (medicine); Mitochondrial DNA; Reactive oxygen species; Chemistry; Biology; Autophagy; Endocrinology; Biochemistry; Apoptosis; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002706768,0.0004497519,0.0008222398,0.0003818539,0.000426329,0.001635198,0.0003679731,0.0009801796,0.004202306],"category_scores_gemma":[0.0004485507,0.00016529,0.0003218708,0.0002755078,0.0006265255,0.0009261907,0.0006887521,0.001527771,0.001810601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000711191,"about_ca_system_score_gemma":0.0004294612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000348206,"about_ca_topic_score_gemma":0.0003996462,"domain_scores_codex":[0.9997494,0.00002407544,0.0000145991,0.00007106449,0.00007269702,0.00006826375],"domain_scores_gemma":[0.9997976,0.00001802804,0.00003760427,0.00004323621,0.0000368889,0.00006654429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009820189,0.00007545383,0.000367233,0.0001792537,0.00001976753,0.0001941186,0.00005299931,0.0001792621,0.9873723,0.002466291,0.0009331492,0.007178248],"study_design_scores_gemma":[0.0001395534,0.0003470308,0.008566601,0.00004477135,0.00003162749,0.0008138166,0.0001667578,0.002884446,0.970107,0.005022704,0.01185437,0.00002134748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9545797,0.004868862,0.01912064,0.002547417,0.0005759976,0.0001146849,0.002186525,0.0007618992,0.01524414],"genre_scores_gemma":[0.9873811,0.0009687566,0.00331657,0.0001878522,0.0001062209,0.0000571139,0.001164771,0.0001625056,0.00665513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004202306,"threshold_uncertainty_score":0.01405811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0718024808223435,"score_gpt":0.4197681696450102,"score_spread":0.3479656888226667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}