{"id":"W4225015507","doi":"10.1002/iub.2618","title":"Towards a metabolomic approach to investigate iron–sulfur cluster biogenesis","year":2022,"lang":"en","type":"article","venue":"IUBMB Life","topic":"Metalloenzymes and iron-sulfur proteins","field":"Energy","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council Canada; Università degli Studi di Torino; Institut Pasteur","keywords":"Biogenesis; Frataxin; Iron–sulfur cluster; Scaffold protein; Enzyme; Chemistry; Biochemistry; In vivo; Metabolomics; In vitro; Sulfur; Sulfur metabolism; Computational biology; Biophysics; Aconitase; Biology; Signal transduction; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007131408,0.0003697975,0.0005248213,0.0002635474,0.0003768464,0.00008442374,0.0007774839,0.00009862849,0.001844301],"category_scores_gemma":[0.0001751885,0.000346547,0.0002574215,0.0007440274,0.00007105759,0.0001373748,0.0008773861,0.0002984421,0.0005761525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001407811,"about_ca_system_score_gemma":0.0002154052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002716657,"about_ca_topic_score_gemma":0.0000564028,"domain_scores_codex":[0.9969404,0.0004316691,0.0005353296,0.0007463917,0.0006610697,0.0006851159],"domain_scores_gemma":[0.9983235,0.00003027666,0.0001407131,0.0008528031,0.00004641536,0.0006062659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001220778,0.002099225,0.001164969,0.0004394962,0.00120172,0.00007461502,0.007921043,0.1707648,0.121407,0.3385011,0.3057435,0.04946185],"study_design_scores_gemma":[0.001146615,0.0001892879,0.001809339,0.00000533706,0.0001178535,0.0000299368,0.0004848583,0.002056889,0.01076368,0.001202815,0.9814694,0.0007239999],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9063985,0.00193867,0.001647077,0.005316358,0.001089044,0.001091069,0.0002040396,0.0003958066,0.08191943],"genre_scores_gemma":[0.9597834,0.00003191963,0.01208564,0.01572295,0.0006055058,0.001105244,0.000123183,0.0001382687,0.0104039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6757259,"threshold_uncertainty_score":0.9998987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02852991646238604,"score_gpt":0.231678739622522,"score_spread":0.203148823160136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}