{"id":"W4225082371","doi":"10.1002/alz.12675","title":"Predictive metabolic networks reveal sex‐ and <i>APOE</i> genotype‐specific metabolic signatures and drivers for precision medicine in Alzheimer's disease","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Qatar National Research Fund; National Institutes of Health; Genentech; National Institute of Neurological Disorders and Stroke; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; University of Southern California; Pfizer; BioClinica; Biogen; Foundation for the National Institutes of Health; Fonds National de la Recherche Luxembourg; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association","keywords":"Apolipoprotein E; Disease; Alzheimer's Disease Neuroimaging Initiative; Precision medicine; Alzheimer's disease; Personalized medicine; Biomarker; Cognitive decline; Metabolomics; Medicine; Bioinformatics; Genotype; Dementia; Biology; Internal medicine; Pathology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001117478,0.0006293341,0.0004378072,0.001111063,0.0002868757,0.00114168,0.0003050961,0.000326362,0.001078982],"category_scores_gemma":[0.002825809,0.000194669,0.0008586596,0.0008451162,0.0002606435,0.000619358,0.0005318315,0.0004623915,0.0001822409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006445045,"about_ca_system_score_gemma":0.0007317736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003808096,"about_ca_topic_score_gemma":0.005256355,"domain_scores_codex":[0.999772,0.00009561877,0.000009779705,0.00007665721,0.00002396443,0.00002196004],"domain_scores_gemma":[0.9991522,0.0004812022,0.0002046966,0.00006696094,0.00005556941,0.00003924754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001150503,0.0002541314,0.5675402,0.0003385866,0.001640223,0.0004569148,0.00026554,0.28894,0.01157808,0.01132259,0.002757391,0.1137559],"study_design_scores_gemma":[0.0000400225,0.0001776907,0.1651563,0.00009954131,0.0005914785,0.0003120758,0.0001841836,0.769595,0.002825607,0.05780461,0.003170292,0.00004317027],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.921083,0.002369219,0.06737485,0.001382192,0.00003470901,0.00005191819,0.00467568,0.0003099559,0.002718458],"genre_scores_gemma":[0.9893918,0.0006239494,0.007939097,0.00008574752,0.00001905621,0.00002283764,0.001583892,0.00001649241,0.00031707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003808096,"threshold_uncertainty_score":0.007571816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01218948035769367,"score_gpt":0.2457774032564885,"score_spread":0.2335879228987948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}