{"id":"W4225082371","doi":"10.1002/alz.12675","title":"Predictive metabolic networks reveal sex‐ and <i>APOE</i> genotype‐specific metabolic signatures and drivers for precision medicine in Alzheimer's disease","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Qatar National Research Fund; National Institutes of Health; Genentech; National Institute of Neurological Disorders and Stroke; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; University of Southern California; Pfizer; BioClinica; Biogen; Foundation for the National Institutes of Health; Fonds National de la Recherche Luxembourg; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association","keywords":"Apolipoprotein E; Disease; Alzheimer's Disease Neuroimaging Initiative; Precision medicine; Alzheimer's disease; Personalized medicine; Biomarker; Cognitive decline; Metabolomics; Medicine; Bioinformatics; Genotype; Dementia; Biology; Internal medicine; Pathology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005625295,0.000311324,0.0004393338,0.0001666931,0.0003636001,0.00002777252,0.0002223687,0.00008642723,0.00004185731],"category_scores_gemma":[0.00003944684,0.0002870523,0.0000903926,0.0002554355,0.0001868023,0.00001434806,0.0005489847,0.0002000735,3.870506e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003069879,"about_ca_system_score_gemma":0.00003394881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003197063,"about_ca_topic_score_gemma":0.00002158042,"domain_scores_codex":[0.9980604,0.0001712653,0.000354595,0.0007521832,0.0002416364,0.0004199036],"domain_scores_gemma":[0.9992009,0.00006189833,0.0001537686,0.000334451,0.00006720171,0.0001817865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.008785165,0.001349012,0.0823803,0.00005609969,0.08401406,0.0001115098,0.003414223,0.008298373,0.2391838,0.02704805,0.1561937,0.3891657],"study_design_scores_gemma":[0.006757975,0.001356245,0.1264522,0.00002678277,0.02287247,0.00002024238,0.0007872815,0.002052281,0.01563761,0.002621623,0.8201713,0.001243996],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.09182488,0.9052132,0.001002223,0.0003610815,0.0004124569,0.0008689181,0.0001513216,0.00001534536,0.0001505902],"genre_scores_gemma":[0.961358,0.03620429,0.0009550168,0.000440765,0.0003454826,0.0003144075,0.0003225456,0.00004141452,0.00001809764],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.8695331,"threshold_uncertainty_score":0.9999582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01218948035769367,"score_gpt":0.2457774032564885,"score_spread":0.2335879228987948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}