{"id":"W4225083498","doi":"10.1007/s12192-022-01275-z","title":"Regulation of the unfolded protein response during dehydration stress in African clawed frogs, Xenopus laevis","year":2022,"lang":"en","type":"article","venue":"Cell Stress and Chaperones","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Unfolded protein response; Xenopus; Biology; Cell biology; Downregulation and upregulation; ATF4; African clawed frog; Transcription factor; Endoplasmic reticulum; Amphibian; Biochemistry; Ecology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007279503,0.0001294715,0.0001418488,0.0002433175,0.0002720739,0.0002534259,0.0001167513,0.0001825689,0.0008163094],"category_scores_gemma":[0.00007507906,0.0001017108,0.0001919716,0.0001006934,0.0002220864,0.0002194582,0.0001760533,0.0002806173,0.0001552159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002175199,"about_ca_system_score_gemma":0.0000955801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001205494,"about_ca_topic_score_gemma":0.002160978,"domain_scores_codex":[0.999943,0.000008659921,0.000004593875,0.00002171418,0.000009377065,0.00001252038],"domain_scores_gemma":[0.9999315,0.000004901836,0.00002972611,0.000004646577,0.00001277316,0.00001655887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008040923,0.00001034485,0.002662818,0.00002766005,0.000004949782,0.00007836093,0.00007414516,0.00003610005,0.9963707,0.00005169353,0.0000207713,0.0005819856],"study_design_scores_gemma":[0.00002046216,0.0008291629,0.602112,0.00003153431,0.00004873856,0.00128925,0.0009009376,0.0008912366,0.389271,0.0001892981,0.004392082,0.00002439806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981938,0.000460302,0.0004052095,0.00003153982,0.0000071944,0.000008847237,0.0002296825,0.0000165877,0.0006469349],"genre_scores_gemma":[0.9962699,0.000337308,0.0009345072,0.0000393931,0.000004019994,0.00002895522,0.0003557277,0.000008359878,0.002021675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001205494,"threshold_uncertainty_score":0.002730846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003995400663863159,"score_gpt":0.1885319916816648,"score_spread":0.1845365910178016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}