{"id":"W4225089707","doi":"10.1101/2022.04.28.489861","title":"An auto-inhibited state of protein kinase G and implications for selective activation","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Basic Energy Sciences; National Institute of General Medical Sciences; National Institutes of Health; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; U.S. Department of Energy; Office of Science; Howard Hughes Medical Institute","keywords":"Allosteric regulation; cGMP-dependent protein kinase; Gene isoform; Phosphorylation; Cyclic nucleotide; Protein kinase A; Biochemistry; Cell biology; Phosphodiesterase; Enzyme activator; Nitric oxide; Linker; Signal transduction; Kinase; Chemistry; Protein structure; Biology; Nucleotide; Enzyme; Mitogen-activated protein kinase kinase; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000263087,0.0002250025,0.0002027466,0.0001173744,0.0001659043,0.00004162303,0.0001360531,0.0001921768,0.000005140804],"category_scores_gemma":[0.000106555,0.0002522268,0.00006843678,0.0001735941,0.00006562223,0.00001240802,0.0001519228,0.0001657538,2.577029e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007232969,"about_ca_system_score_gemma":0.0003061046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002019427,"about_ca_topic_score_gemma":0.000002070243,"domain_scores_codex":[0.9987295,0.0000966614,0.0003007261,0.0005941557,0.00009760817,0.0001813456],"domain_scores_gemma":[0.998522,0.00001326547,0.0003714607,0.0005599215,0.000437397,0.00009594451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001467558,0.0001158551,0.001471546,0.0001713224,0.00007479129,1.647586e-7,0.00000707391,0.0002647376,0.9974758,0.0001759872,0.00007911144,0.00001684277],"study_design_scores_gemma":[0.0004118886,0.0002377362,0.110711,0.00004654199,0.00002810858,6.408288e-9,0.000002096406,0.0004756197,0.8841606,0.00001561661,0.003650852,0.0002599166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809406,0.0002131549,0.01670656,0.0001399088,0.000124687,0.0012992,0.0005175808,0.00005574384,0.00000252203],"genre_scores_gemma":[0.9959446,0.00004813648,0.002947242,0.0000565855,0.0001018175,0.0008130312,0.00001952966,0.00005393499,0.00001510518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1133152,"threshold_uncertainty_score":0.999993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01027050936040888,"score_gpt":0.2387617437249646,"score_spread":0.2284912343645557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}