{"id":"W4225103612","doi":"10.1055/a-1778-5125","title":"Epigenetics for Drug Discovery: Dissecting the Effect of High Antipsychotic Dosage and D2 Blockage on Peripheral DNA Methylation","year":2022,"lang":"en","type":"article","venue":"Pharmacopsychiatry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"DNA methylation; Antipsychotic; Epigenetics; Methylation; Pharmacology; Biology; Medicine; Genetics; Gene; Schizophrenia (object-oriented programming); Gene expression; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005879507,0.0001846556,0.0001778617,0.00004412041,0.0003795649,0.00003238057,0.0001822548,0.00004202435,0.00002197954],"category_scores_gemma":[0.00005424195,0.0001458051,0.0001235828,0.0001204919,0.00005299053,0.000005732807,0.0001001644,0.0001480427,2.928247e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001430796,"about_ca_system_score_gemma":0.0000261145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001848273,"about_ca_topic_score_gemma":0.000007456802,"domain_scores_codex":[0.9986933,0.0002932921,0.0002592594,0.0003549465,0.0001919044,0.0002073044],"domain_scores_gemma":[0.9993306,0.0001315263,0.0001854861,0.0002690218,0.00003593037,0.00004747512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001039286,0.00009159997,0.01507677,0.0001091134,0.0001256775,3.764931e-7,0.0001861686,0.004570226,0.9671695,0.0001426127,0.0006951103,0.01079355],"study_design_scores_gemma":[0.002501071,0.001734965,0.01073836,0.00001211725,0.0001584195,0.00000246218,0.000138665,0.001190483,0.9771042,0.0006494498,0.005492932,0.0002768153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913806,0.00404059,0.001930829,0.0003225743,0.001441015,0.0006526503,0.0001102715,0.000009375869,0.0001121183],"genre_scores_gemma":[0.9983389,0.0002269423,0.0003395104,0.0001141576,0.0004553448,0.0001232612,0.000134012,0.00003769753,0.0002301264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01051674,"threshold_uncertainty_score":0.5945757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006164298889106406,"score_gpt":0.2779114913895937,"score_spread":0.2717471925004873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}