{"id":"W4225104640","doi":"10.1001/jamaoncol.2022.0615","title":"Assessment of Toxic Effects and Survival in Treatment Deescalation With Radiotherapy vs Transoral Surgery for HPV-Associated Oropharyngeal Squamous Cell Carcinoma","year":2022,"lang":"en","type":"article","venue":"JAMA Oncology","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; University of Ottawa; University of Calgary; McGill University; Princess Margaret Cancer Centre; University Health Network; University of Toronto; Health Sciences Centre; University of British Columbia; Sunnybrook Health Science Centre; Western University","funders":"","keywords":"Medicine; Clinical endpoint; Neck dissection; Radiation therapy; Internal medicine; Randomized controlled trial; Surrogate endpoint; Oncology; Quality of life (healthcare); Head and neck squamous-cell carcinoma; Chemoradiotherapy; Surgery; Cancer; Head and neck cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00398699,0.0008550394,0.001468091,0.0003428952,0.0003105021,0.0007124742,0.000634705,0.001140537,0.002747979],"category_scores_gemma":[0.003332533,0.0003886211,0.002066911,0.0003462544,0.0008206,0.0008017669,0.0004554479,0.001922195,0.0002526703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009839827,"about_ca_system_score_gemma":0.001566753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006117413,"about_ca_topic_score_gemma":0.001941637,"domain_scores_codex":[0.9980456,0.001260233,0.0001650866,0.0001978172,0.0001759062,0.0001553995],"domain_scores_gemma":[0.9977912,0.000798441,0.0007364754,0.0001228148,0.0001332767,0.0004178187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9233931,0.01843483,0.006847339,0.0006849536,0.001552993,0.00002571381,0.00008037939,0.001218398,0.005119956,0.0001532208,0.0002805551,0.04220867],"study_design_scores_gemma":[0.2609999,0.7126539,0.01796919,0.00009622298,0.001814661,0.00007162178,0.00007614762,0.001703931,0.003210649,0.0003084434,0.001068103,0.00002719346],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948584,0.001869979,0.0003951056,0.000168168,0.0001356982,0.001501565,0.0001341995,0.00001118608,0.0009257162],"genre_scores_gemma":[0.9959382,0.0007566339,0.0006811634,0.0001921223,0.0001402561,0.00162528,0.00011205,0.000003717683,0.0005506842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00398699,"threshold_uncertainty_score":0.02108544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02076021737752025,"score_gpt":0.3136201558589964,"score_spread":0.2928599384814761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}