{"id":"W4225120401","doi":"10.1126/scitranslmed.abo0718","title":"Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms","year":2022,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":252,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Biology; RNA-dependent RNA polymerase; Virology; Polymerase; RNA polymerase; Coronaviridae; Nonsynonymous substitution; Genetics; RNA; Coronavirus; Nucleoside; Viral replication; Gene; Virus; Coronavirus disease 2019 (COVID-19); Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002937055,0.0001893168,0.000274376,0.0005351972,0.0006987335,0.00003740186,0.0007017194,0.00002960868,0.0001437837],"category_scores_gemma":[0.0004614029,0.0001358017,0.00005740107,0.002531296,0.0007300269,0.0001763992,0.00005355157,0.0004867657,0.00002944853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002171615,"about_ca_system_score_gemma":0.001012271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004341384,"about_ca_topic_score_gemma":0.0005079671,"domain_scores_codex":[0.9949892,0.0001744028,0.0004588419,0.000598188,0.003257492,0.0005219062],"domain_scores_gemma":[0.9988096,0.0004186673,0.0000709402,0.0004336777,0.0001864298,0.00008063647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003529453,0.0001899411,0.0007610167,0.00002322975,0.00001026309,0.0001381132,0.003604024,0.000007482416,0.9786796,0.01291885,0.001545294,0.001769235],"study_design_scores_gemma":[0.01078991,0.001867644,0.02844348,0.0003666428,0.0001707762,0.000338137,0.008858871,0.002399826,0.8014514,0.03420876,0.1102185,0.0008860681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8561466,0.001012448,0.01446732,0.1010496,0.0004677754,0.001915175,0.0001641725,0.00008183201,0.02469501],"genre_scores_gemma":[0.9430106,0.000001282458,0.000374785,0.0560782,0.0000971842,0.0002421716,0.00002579579,0.00001637033,0.0001536487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1772282,"threshold_uncertainty_score":0.5537833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05343227246204882,"score_gpt":0.368814440496167,"score_spread":0.3153821680341181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}