{"id":"W4225126422","doi":"10.2217/pgs-2022-0010","title":"Characterization of the Impact of the <i>MYBBP1A</i> Gene and rs3809849 on Asparaginase Sensitivity and Cellular Functions","year":2022,"lang":"en","type":"article","venue":"Pharmacogenomics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Leukemia and Lymphoma Society of Canada; Cancer Research Society","keywords":"Asparaginase; Apoptosis; Allele; CRISPR; Molecular biology; Cell culture; Cell cycle; Mutant; Cell growth; Mesenchymal stem cell; Wild type; Cancer research; Gene; Leukemia; Biology; Chemistry; Lymphoblastic Leukemia; Cell biology; Immunology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001543685,0.0002432591,0.0002394961,0.0001764797,0.000133857,0.0002106156,0.0002141183,0.0003729917,0.002526997],"category_scores_gemma":[0.0002370223,0.0001142304,0.0003257987,0.0001781102,0.0001914926,0.00009506373,0.0001478355,0.0005334775,0.0005666785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002208332,"about_ca_system_score_gemma":0.0001713464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001011582,"about_ca_topic_score_gemma":0.001269025,"domain_scores_codex":[0.9998199,0.00001660983,0.00001515899,0.00005879168,0.00006783233,0.00002170453],"domain_scores_gemma":[0.9998474,0.00003132996,0.00006288505,0.00001959103,0.00001343497,0.00002525988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002540191,0.00001997948,0.002847112,0.0000678729,0.00002446206,0.0002620466,0.00002107229,0.0001784633,0.9927083,0.00007120675,0.00008745375,0.003457946],"study_design_scores_gemma":[0.00006210741,0.0005189513,0.08053329,0.00002129227,0.0001457829,0.00437915,0.00008027936,0.001783315,0.9031658,0.0001986166,0.009092446,0.00001888223],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936097,0.000921201,0.002503684,0.0001384211,0.00002546666,0.00003030661,0.00151275,0.00008951448,0.001168904],"genre_scores_gemma":[0.9945852,0.000430984,0.002009175,0.00007873828,0.00000613548,0.000043099,0.001184778,0.00004275634,0.001619111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002526997,"threshold_uncertainty_score":0.008453667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006904262549461898,"score_gpt":0.2595792477075251,"score_spread":0.2526749851580631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}