{"id":"W4225126422","doi":"10.2217/pgs-2022-0010","title":"Characterization of the Impact of the <i>MYBBP1A</i> Gene and rs3809849 on Asparaginase Sensitivity and Cellular Functions","year":2022,"lang":"en","type":"article","venue":"Pharmacogenomics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Leukemia and Lymphoma Society of Canada; Cancer Research Society","keywords":"Asparaginase; Apoptosis; Allele; CRISPR; Molecular biology; Cell culture; Cell cycle; Mutant; Cell growth; Mesenchymal stem cell; Wild type; Cancer research; Gene; Leukemia; Biology; Chemistry; Lymphoblastic Leukemia; Cell biology; Immunology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001133531,0.00007313008,0.00006995281,0.0000137653,0.0001021738,0.000003837251,0.00005844046,0.00001799473,0.000006235527],"category_scores_gemma":[0.000006749594,0.00005261849,0.00006280044,0.0000588887,0.00004491057,0.000001346497,0.0001776217,0.00006874959,9.977949e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001107252,"about_ca_system_score_gemma":0.00002881267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002223047,"about_ca_topic_score_gemma":0.000002389399,"domain_scores_codex":[0.9996004,0.00006019644,0.00009139567,0.0001165235,0.00005628842,0.00007519199],"domain_scores_gemma":[0.9997198,0.000007583867,0.00006398359,0.0001655682,0.00001862814,0.00002446324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003898759,0.00002917439,0.004720027,0.000007762841,0.00003829151,3.046138e-7,0.00005549335,0.007804445,0.9868035,0.000003210219,0.00003738803,0.0004613845],"study_design_scores_gemma":[0.000244264,0.00006273777,0.02112941,0.000001572633,0.00003216885,0.00001852574,0.00001395754,0.001740367,0.9757652,0.000002806897,0.0009323598,0.00005661418],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984601,0.0002485793,0.000639304,0.00005636285,0.0001335872,0.0001431893,0.0002860293,0.000001976272,0.0000308533],"genre_scores_gemma":[0.9996778,0.00009648534,0.00001149241,0.00006438922,0.00004786054,0.000005864357,0.00003507145,0.000009970347,0.00005108713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01640938,"threshold_uncertainty_score":0.214572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006904262549461898,"score_gpt":0.2595792477075251,"score_spread":0.2526749851580631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}