{"id":"W4225128244","doi":"10.1212/wnl.0000000000200384","title":"Longitudinal Cognitive Changes in Genetic Frontotemporal Dementia Within the GENFI Cohort","year":2022,"lang":"en","type":"article","venue":"Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Instituto de Salud Carlos III; Medical Research Council; Fonds de Recherche du Québec - Santé; National Institutes of Health; Janssen Pharmaceuticals; Dementias Platform UK; Stichting Dioraphte; Bayer Vital; Evelyn Trust; Novo Nordisk; KU Leuven; Vetenskapsrådet; Eisai; Ministero della Salute; Canadian Institutes of Health Research; Fonds Wetenschappelijk Onderzoek; Fundação para a Ciência e a Tecnologia; Karolinska Institutet; Alzheimer's Drug Discovery Foundation; Weston Brain Institute; ZonMw; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Fondation Brain Canada; Denali Therapeutics; EU Joint Programme – Neurodegenerative Disease Research; Advocacy for Neuroacanthocytosis Patients; Alzheimer's Association; Astex Pharmaceuticals; Sunovion; Alzheimer Nederland; Biogen; AstraZeneca; Brain Research UK; Eli Lilly and Company; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; Deutsche Forschungsgemeinschaft; Ionis Pharmaceuticals","keywords":"C9orf72; Frontotemporal dementia; Dementia; Cohort; Cognitive decline; Neuropsychology; Clinical Dementia Rating; Executive dysfunction; Disease; Frontotemporal lobar degeneration; Oncology; Psychology; Executive functions; Medicine; Cognition; Internal medicine; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003701512,0.000110584,0.0002135094,0.0001002607,0.0001577478,0.000008624655,0.0001747681,0.00005304635,0.001717191],"category_scores_gemma":[0.00005801759,0.00008087132,0.00003754719,0.0002095779,0.0001708292,0.00001750596,0.0003164354,0.0007202306,0.00003847194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004092992,"about_ca_system_score_gemma":0.00008324613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001110557,"about_ca_topic_score_gemma":0.001441599,"domain_scores_codex":[0.9982819,0.0004420294,0.0001867907,0.0003502277,0.0003872706,0.0003517874],"domain_scores_gemma":[0.9995201,0.00009526292,0.00006184679,0.0002112681,0.00003965417,0.0000719311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009847917,0.00009043243,0.9957507,0.000006208669,0.00007737555,0.0006294503,0.0002411989,0.00007166543,0.00105394,0.0000254475,0.00037788,0.0006908879],"study_design_scores_gemma":[0.001118999,0.002043607,0.9944267,0.000002947857,0.00006379639,0.0002762205,0.00003071983,0.0009331955,0.00003507283,0.00008654975,0.0009167219,0.0000654207],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861455,0.0004111463,0.00001557281,0.01204092,0.0002117943,0.0006874768,0.000009155246,0.00002414827,0.0004543168],"genre_scores_gemma":[0.9946451,0.00003665353,0.00003083918,0.004644723,0.0001330138,0.0003224384,0.00001763337,0.00002111499,0.0001485063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008499607,"threshold_uncertainty_score":0.9991954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03732362748179292,"score_gpt":0.295417211045417,"score_spread":0.2580935835636241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}