{"id":"W4225128244","doi":"10.1212/wnl.0000000000200384","title":"Longitudinal Cognitive Changes in Genetic Frontotemporal Dementia Within the GENFI Cohort","year":2022,"lang":"en","type":"article","venue":"Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Instituto de Salud Carlos III; Medical Research Council; Fonds de Recherche du Québec - Santé; National Institutes of Health; Janssen Pharmaceuticals; Dementias Platform UK; Stichting Dioraphte; Bayer Vital; Evelyn Trust; Novo Nordisk; KU Leuven; Vetenskapsrådet; Eisai; Ministero della Salute; Canadian Institutes of Health Research; Fonds Wetenschappelijk Onderzoek; Fundação para a Ciência e a Tecnologia; Karolinska Institutet; Alzheimer's Drug Discovery Foundation; Weston Brain Institute; ZonMw; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Fondation Brain Canada; Denali Therapeutics; EU Joint Programme – Neurodegenerative Disease Research; Advocacy for Neuroacanthocytosis Patients; Alzheimer's Association; Astex Pharmaceuticals; Sunovion; Alzheimer Nederland; Biogen; AstraZeneca; Brain Research UK; Eli Lilly and Company; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; Deutsche Forschungsgemeinschaft; Ionis Pharmaceuticals","keywords":"C9orf72; Frontotemporal dementia; Dementia; Cohort; Cognitive decline; Neuropsychology; Clinical Dementia Rating; Executive dysfunction; Disease; Frontotemporal lobar degeneration; Oncology; Psychology; Executive functions; Medicine; Cognition; Internal medicine; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001072158,0.0003272509,0.0002541024,0.0006800976,0.0006234076,0.0005208488,0.0004100445,0.0005198122,0.001077035],"category_scores_gemma":[0.001319126,0.0002087449,0.0006188857,0.0006847258,0.0002558359,0.0003073431,0.0004356856,0.0005078294,0.0001959299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004585738,"about_ca_system_score_gemma":0.0004545249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.04333954,"about_ca_topic_score_gemma":0.04929635,"domain_scores_codex":[0.9996986,0.00006154935,0.0000196233,0.0001185513,0.00004101252,0.00006057097],"domain_scores_gemma":[0.999512,0.00007402636,0.0001650403,0.00009776961,0.00006031769,0.00009092277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004339072,0.00002800201,0.9967108,0.000005832284,0.0001451509,0.0001857246,0.0001382146,0.00006932832,0.000452027,0.00003661745,0.0002654136,0.001528967],"study_design_scores_gemma":[0.00001095499,0.00005566786,0.9993181,0.000002908318,0.00004433774,0.0001594711,0.0000745194,0.00008511997,0.00004662682,0.00002788314,0.0001706615,0.000003553179],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985115,0.0001283471,0.0000761442,0.00003411738,0.000006127903,0.000005422931,0.0009845319,0.000005700042,0.0002481518],"genre_scores_gemma":[0.9984433,0.00007138662,0.0001271135,0.00002829462,0.000006762343,0.00001469229,0.001089065,0.000002808118,0.0002165045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04333954,"threshold_uncertainty_score":0.08617455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03732362748179292,"score_gpt":0.295417211045417,"score_spread":0.2580935835636241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}