{"id":"W4225130908","doi":"10.1016/j.jtho.2022.04.011","title":"A Large-Scale Genome-Wide Gene-Gene Interaction Study of Lung Cancer Susceptibility in Europeans With a Trans-Ethnic Validation in Asians","year":2022,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; BC Cancer Agency; Princess Margaret Cancer Centre; University of British Columbia; University of Toronto","funders":"National Cancer Institute; National Key Research and Development Program of China; Jiangsu Planned Projects for Postdoctoral Research Funds; National Institute of Environmental Health Sciences; Government of Jiangsu Province; Qinglan Project of Jiangsu Province of China; National Institutes of Health; Nanjing Medical University; National Natural Science Foundation of China; Priority Academic Program Development of Jiangsu Higher Education Institutions; Natural Science Foundation of Jiangsu Province; World Health Organization; National Institute on Aging; Centre International de Recherche sur le Cancer; Medical Research Council; China Postdoctoral Science Foundation","keywords":"Medicine; Gene; Ethnic group; Lung cancer; Genetics; Genome; Scale (ratio); Oncology; Biology; Anthropology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002092477,0.000471519,0.0004927778,0.0008453795,0.0009222277,0.000547281,0.0004364625,0.0004690724,0.002147631],"category_scores_gemma":[0.002562278,0.0002157804,0.0012734,0.001494001,0.0003729254,0.0002174934,0.0007541422,0.0004160491,0.0002831247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002212001,"about_ca_system_score_gemma":0.0004577723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006362965,"about_ca_topic_score_gemma":0.007022395,"domain_scores_codex":[0.9988869,0.0004604099,0.0000953799,0.0003557141,0.0001003332,0.0001012505],"domain_scores_gemma":[0.9987715,0.0003937072,0.0002245449,0.0002712556,0.0001290317,0.0002099572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004467014,0.00008873752,0.9892687,0.00002824227,0.0007223483,0.0004938824,0.0003300359,0.0001756827,0.004353996,0.0001010322,0.0001714844,0.003819137],"study_design_scores_gemma":[0.00002346277,0.0001567951,0.9973292,0.000008548665,0.0003870992,0.0004376944,0.0002204697,0.0005425179,0.0004027712,0.00009383471,0.0003896095,0.000007962088],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983435,0.0001303355,0.0008830819,0.0000364185,0.000005054474,0.00001072787,0.0003899814,0.000007680635,0.0001933308],"genre_scores_gemma":[0.998445,0.0000532082,0.000735994,0.00003904205,0.000006645329,0.00001577872,0.0005314575,0.000007215541,0.0001657126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006362965,"threshold_uncertainty_score":0.01265186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02318064078825642,"score_gpt":0.3867385410856358,"score_spread":0.3635579002973793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}